Cardiology - Arrhythmias: Bradycardias Flashcards

1
Q

In bradycardia induced intrinsically by coronary artery disease, which territory is associated?

A

Inferior infarcts

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2
Q

What is the most common cause of sinus bradycardia?

A

Age related myocardial fibrosis

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3
Q

Familial sinus bradycardia: SSS1

A
SSS1:
- autosomal RECESSIVE
- mutation: SCN5A gene on Ch3
(Cardiac Na channel gene)
- prominent atrial inexcitability
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4
Q

Familial sinus bradycardia: SSS2

A

SSS2
- autosomal DOMINANT
- mutation: HCN4 on Ch15
(Pacemaker current If gene)

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5
Q

Familial Sinus Bradycardia: SSS3

A

SSS3

  • SA node dysfunction
  • mutation: myosin heavy chain 6 (MYH6)
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6
Q

Familial sick sinus syndrome:

Which mutation in SSS1

A

SCN5A on Ch3

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7
Q

Familial sick sinus syndrome:

Which mutation is SSS2?

A

HCN4 on Ch15

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8
Q

Familial sick sinus syndrome:

Which mutation in SSS3?

A

MYH6 gene

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9
Q

SCN5A mutation on which chromosome and which familial syndrome?

A

SCN5A on Ch3 in SSS1

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10
Q

HCN4 mutation on which chromosome and which familial syndrome?

A

HCN4 on Ch15 in SSS2

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11
Q

Which neuromuscular conditions are associated with sinus bradycardia?

A
  • Kearns-Sayre Syndrome
  • Myotonic dystrophy
  • Freidreich’s ataxia
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12
Q

Treatment of sinus bradycardia?

A

Treatment is aimed at symptoms

Sinus node dysfunction DOES NOT increase MORTALITY

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13
Q

Indication for PPM in sinus bradycardia?

A

Class 1 Indications:

  • SYMPTOMS associated
  • AF with bradycardia and pauses >5 seconds

Class 2 Indications:

  • Sinus node dysfunction with rate <40bpm
  • syncope without known cause and evidence of Sinus Node Dysfunction on EP Study
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14
Q

What electrolyte or endocrine caused for AV block?

A
  • hypERkalaemia
  • hypERmagnesaemia
  • hyPOthyroidism
  • adrenal insufficiency
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15
Q

Drug related causes of AV block?

A
Beta blocker or CCB
Digoxin
Adenosine
Class I and III Antiarrhythmics 
Lithium
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16
Q

Infectious Diseases associated with AV block?

A
  • endocarditis
  • Lyme disease
  • diphtheria
  • TB
  • Chagas’ disease
  • Syphilis
17
Q

Inflammatory and Infiltrative diseases associated with AV block?

A
SLE
RA
MCTD
Scleroderma
Amyoidosis
Sarcoidosis
Haemochrlmatosis
18
Q

Neoplastic disease associated with AV block?

A

Lymphoma
Mesothelioma
Melanoma
RTx

19
Q

Degenerative Diseases associated with AV block?

A

Lev’s disease

Lenegre disease

20
Q

Definition of 1st degree AV Block?

A

PR > 200ms

21
Q

Management of 1st degree AV block?

A

Usually benign

NOT indication for PPM

22
Q

Although 1st degree AV block is generally considered benign, what adverse outcomes is it associated with?

A
  • increased risk AF
  • increased risk PPM requirement
  • increased all-cause mortality
23
Q

2nd degree AV Block: definitions

A

Type 1: Wenkebach
- progressive prolongation with single nonconducted P wave with pause

Type 2
-CONSTANT PR interval but non-conducted P waves

24
Q

Where is the block located in Type 1 versus type 2 second degree AV block?

A

In Type 1 the block is at the AV node

In Type 2 the block is lower down in the conduction system

25
Q

Management of Type I vs Type II 2nd degree block?

A

Type I:

  • usually benign, normal fit patients
  • improves with exercise or increased sympathetic tone
  • NOT an indication for PPM

Type II:

  • HIGHER risk of progression to complete heart block
  • needs PPM if symptoms or if very bradycardic
26
Q

Treatment of Third Degree heart block?

A
  • PPM indicated (unless asymptomatic with rate >40bpm)

- poor prognosis if it is associated with an anterior MI

27
Q

What gives a particularly poor prognosis in 3rd degree AV block?

A

Association with an anterior MI

28
Q

Maternal antibodies associated with congenital complete heart block?

A

Anti-Ro (SS-A)

Anti-La (SS-B)

29
Q

Other than maternal antibodies what other rheumatological condition is associated with congenital complete heart block?

A

Maternal lupus

30
Q

What are Morgagni-Adams-Stokes (MAS) episodes?

A

Syncopal episodes due to bradycardia

31
Q

Biventricular versus RV-Only PPM - when might a biventricular be especially indicated?

A

Biventricular is better in HF with AV block

  • reduced hospitalisation
  • increased SURVIVAL
32
Q

Indications for PPM in AV Block?

A

1) 3rd degree with:
- symptoms
- episodes of asystole >3 seconds or AWAKE RATE <40bpm
- post op AV block not expected to resolve
- AV node ablation
- presence of neuromuscular disease

2) second degree block with symptoms
3) Type II second degree with wide QRS
4) Exercise induced 2nd or 3rd block WITHOUT ischaemia
5) AF with pause >5 seconds

33
Q

Indications for TEMPORARY PACING?

A
  • symptomatic or unstable bradycardia not responding to atropine
  • Post-ANTERIOR MI with Type 2 second degree or third degree block
  • Trifascicular block prior to surgery
34
Q

Between Anterior and Inferior myocardial infarction associated AV block which is better?

A

AV block post inferior MI is COMMON and can be managed conservatively if stable and asymptomatic

35
Q

Complications of pacing?

A
  • tamponade
  • haemothorax
  • pneumothorax
  • PPM dysfunction
  • lead fracture
36
Q

Best test to decide if CRT indicated?

A

TTE and ECG

  • LVEF<35%
  • ECG with LBBB

These have EXERCISE TOLERANCE and a QOL benefit

37
Q

What happens with a magnet on either a PPM or ICD?

A

Turns PPM on

Turns ICD off