Cardiology - Arrhythmias: Bradycardias Flashcards
In bradycardia induced intrinsically by coronary artery disease, which territory is associated?
Inferior infarcts
What is the most common cause of sinus bradycardia?
Age related myocardial fibrosis
Familial sinus bradycardia: SSS1
SSS1: - autosomal RECESSIVE - mutation: SCN5A gene on Ch3 (Cardiac Na channel gene) - prominent atrial inexcitability
Familial sinus bradycardia: SSS2
SSS2
- autosomal DOMINANT
- mutation: HCN4 on Ch15
(Pacemaker current If gene)
Familial Sinus Bradycardia: SSS3
SSS3
- SA node dysfunction
- mutation: myosin heavy chain 6 (MYH6)
Familial sick sinus syndrome:
Which mutation in SSS1
SCN5A on Ch3
Familial sick sinus syndrome:
Which mutation is SSS2?
HCN4 on Ch15
Familial sick sinus syndrome:
Which mutation in SSS3?
MYH6 gene
SCN5A mutation on which chromosome and which familial syndrome?
SCN5A on Ch3 in SSS1
HCN4 mutation on which chromosome and which familial syndrome?
HCN4 on Ch15 in SSS2
Which neuromuscular conditions are associated with sinus bradycardia?
- Kearns-Sayre Syndrome
- Myotonic dystrophy
- Freidreich’s ataxia
Treatment of sinus bradycardia?
Treatment is aimed at symptoms
Sinus node dysfunction DOES NOT increase MORTALITY
Indication for PPM in sinus bradycardia?
Class 1 Indications:
- SYMPTOMS associated
- AF with bradycardia and pauses >5 seconds
Class 2 Indications:
- Sinus node dysfunction with rate <40bpm
- syncope without known cause and evidence of Sinus Node Dysfunction on EP Study
What electrolyte or endocrine caused for AV block?
- hypERkalaemia
- hypERmagnesaemia
- hyPOthyroidism
- adrenal insufficiency
Drug related causes of AV block?
Beta blocker or CCB Digoxin Adenosine Class I and III Antiarrhythmics Lithium