Pregnancy Flashcards
CARDIOLOGY:
What are the highest maternal risk factors?
- severe pulmonary hypertension
- Eisenmenger
- Cardiomyopathy with EF<40% and NYHA II
- Severe obstructive cardiac lesions (AS, PS, MS)
- Marfans with Ao root >40mm
- Previous severe peripartum CM
CARDIOLOGY:
ASD in pregnancy?
ASDs are usually well tolerated but there is risk of paradoxical embolism
CARDIOLOGY:
VSD in pregnancy?
VSD is okay if it is restrictive
CARDIOLOGY:
Marfan, Bicuspid Ao and Coarctation in pregnancy?
Risk for dissection
CARDIOLOGY:
Peripartum cardiomyopathy features?
Last trimetester, or early postpartum
LVEF improves in 50% at 6 months post partum
High recurrence risk
CARDIOLOGY:
What are the changes to the cardiovascular physiology that occur in pregnancy?
- increased plasma volume
- increased total blood volume
- relative anaemia
- increased heart rate and cardiac output
- decreased systemic vascular resistance
- decreased mean arterial pressure
CARDIOLOGY:
How do you estimate CVS complications in pregnancy in women with CVS disease?
CARPREG index.
CARDIOLOGY:
Which delivery method is preferred in pregnancy with hx of CVS disease?
Vaginal delivery
BUT if they are on warfarin then prefer caesarian to reduce risk of foetal intracranial haemorrhage
CARDIOLOGY:
Risk factors for peri-partum cardiomyopathy?
Multiparous Older age >30yrs Black Multifoetal Gestational hypertension Preeclampsia Treatment with tocolytics
CARDIOLOGY:
Which antihypertensive treatments BUT you avoid due to teratotoxicity?
ACEi, ARB and aldosterone antagonists
CARDIOLOGY:
In which conditions is pregnancy contraindicated?
- pulmonary arterial hypertension of any cause
- severe systemic ventricular dysfunction with EF<30, NYHA III-IV
- Pervious peripartum cardiomyopathy with any residual impairment of LVEF
- Marfan with Ao dilated >45mm
or Aortic dilation >50mm in aortic disease with BICUSPID valve - severe mitral stenosis or severe symptomatic aortic stenosis
- native severe coarctation
CARDIOLOGY:
Recommendations for mitral stenosis in pregnancy?
- Intervention prior to pregnancy
- If symptoms or pulmonary hypertension then restrict activities and give beta-1 selective blockers
- Diuretics if congestive symptoms despite beta blockers
- Anticoagulate if AF, atrial thrombus or previous embolism
- Consider percutaneous mitral commissurotomy if pregnant with severe symptoms or systolic PAP>50mmHg despite medications
CARDIOLOGY:
Recommendations for aortic stenosis in pregnancy?
Undergo interventio prior to pregnancy if:
- symptomatic
- LVEF<50%
Asymptomatic patients need exercise testing pre-pregnancy
THYROID:
What is the relationship between betahCG and TSH?
betahCG and TSH share a common alpha-subunit
–> so beta-hCG mildly suppresses TSH
THROID:
Hyperemesis in the 1st trimester is associated with what abnormalities of thyroid function?
Hyperemesis in 1st trimester is associated with HIGH beta-HCG –> Suppresses TSH and High T3/T4
THROID:
What to do with thyroxine dose in pregnancy?
Increase the dose!!
THROID:
Antithyroid antibodies are associated with what in pregnancy?
Anti-thyroid antibodies are a risk factor for:
- miscarriage
- prematurity
Anti-TSH-R antibodies are associated with:
- increased risk neonatal thyrotoxicosis
THROID:
When does the foetus produce its own thyroid hormone?
20 weeks
THROID:
Complications of hypothyroidism in pregnancy?
What to do with hypothyroidism in pregnancy?
Complications of hypothyroidism in pregnancy:
- impaired foetal cognitive and neuropsych development
- miscarriage
- IUGR
- Preeclampsia
Treat to target TSH <2.5 and (controversial) if antibody positive
THROID:
Causes of hyperthyroidism in pregnancy?
Transient hCG effect
Hyperemesis
Graves is MOST COMMON