Wk 28 - Commonly prescribed drugs 4 Flashcards
Which medications interact with methotrexate?
- NSAID: red renal blood flow + excretion of MXT
- Diuretic: red blood vol tf red glomerular filtration rate
- ACEi: red glomerular pressure
What are the s/e of metoclopramide?
Dystonic reactions:
- Facial + skeletal muscle spasm
- Oculogyric crises
Neurological effects:
- Extrapyramidal disorders
- Tardive dyskinesia
When would you prescribe metoclopramide?
> 18 yrs:
- Prevent postoperative N+V
- Radiotherapy induced N+V
- Delayed cheo N+V
- Acute migraine
How long should metoclopramide be prescribed for?
Upto 5 days
What is the usual dose of metoclopramide?
10mg repeated upto TDS, max 500mcg/kg
What is metronidazole?
High activity against anaerobic bacteria
When metronidazole is taken with alcohol, what symptoms would you expect?
- Flushing
- Feeling sick
- Headache
- DIzziness
- Palpitations
Can you take alcohol w/ metronidazole?
No - avoid during + 48hrs after
When would you avoid nitrofurantoin + be cautious of commening?
- Avoid: eGFR <45
- Cautious: eGFR 30-44
What are the adverse effects of quinine sulphate that you may experience + stop if it occurs?
- Tinnitus
- Impaired hearing
- Flushing
- Thrombocytopenia: bruising, bleeding
What are the interactions of quinine?
- Digoxin + warfarin
- OD: death + permanent visual loss
When would you prescribe quinine sulphate + how often is it assessed?
- Trial for 4 wks
- If continues asses every 3 months
When would you be cautious of using tramadol?
Taking meds that lower seizure threshold - SSRI + TCA
What are the interactions of trimethoprim?
- ACE: inc hyperkalaemia
- MXT: inc haematological toxicity + anti-folate (teratogenic)
