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E 1.2: Histology, Anatomy, Pathology, and Infectious Diseases Lab > Week 9: Uterine Pathology > Flashcards

Week 9: Uterine Pathology Flashcards

1
Q

ID the normal Endometrium phases

A

Left - Proliferative
Right - Mid-Secretory

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2
Q

What are 4 non-malignant uterine pathologies

A
  • Serosal Endometriosis
  • Benign Hyperplasia
  • Adenomyosis
  • Atypical Hyperplasia
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3
Q

ID

A

Endometriosis

powder burns (black arrow)

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4
Q

What are common locations for endometriosis

A
  • Pelvic and Abdominal Parietal Peritoneum
  • Adnexal structures - ovaries, uterine tube, broad ligament and other ligaments
  • Bowel Visceral Peritoneum
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5
Q

ID

biopsy taken from the rectouterine pouch
A

Endometriosis

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6
Q

ID

A

Endometrioma (Chocolate Cyst)

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7
Q

ID

A

Endometrial Polyp

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8
Q

ID

A

Endometrial Polyp

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9
Q

ID

left - normal; right - abnormal
A

Endometrial Typical Hyperplasia

Increased number of glands

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10
Q

What is the most common cause of endometrial hyperplasia?

A

unopposed estrogen stimulation

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11
Q

ID

A

Endometrial Atypical Hyperplasia

Back-to-back glands with no intervening stroma (yellow arrow)

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12
Q

What are 2 Epithelial Uterine Malignancies

A
  • Endometrioid Carcinonoma (Type 1)
  • Serous Carcinoma (Type 2)
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13
Q

ID

A

Endometrioid Endometrial Carcinoma (Type 1)

resembles endometrial glands

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14
Q

What mutation is associated with Endometrial Atypical Hyperplasia and Endometrioid Endometrial Carcinoma (Type 1)?

A

PTEN

Phosphate Tensin homologous deletion

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15
Q

Who gets Endometrioid Endometrial Carcinoma (Type 1)

A
  • 55-65 year olds
  • PMH of obesity, hypertension, and diabetes
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16
Q

ID

A

Serous Endometrial Carcinoma (Type 2)

17
Q

What mutation is associated with Serous Endometrial Carcinoma (Type 2)?

18
Q

Who gets Serous Endometrial Carcinoma (Type 2)

A
  • 65-75 year olds
  • Postmenopausal status
19
Q

ID

A

Endometrioid Endometrial Carcinoma (Type I)

Left to Right is progressed grading

20
Q

ID

A

Serous Endometrial Carcinoma (Type 2)

Left to Right is progressed grading

21
Q

What is the treatment for Endometrial Carcinoma?

A

Hysterectomy and Bilateral Salpingo-oophorectomy with lymph node sampling

22
Q

ID

A

Endometrial Carcinoma (Asterisk)
Myometrial Invasion (Black Arrow)
Leiomyoma/Fibroid (Plus Sign)

23
Q

benign smooth muscle neoplasm, sharply circumscribed, round, light tan and firm. They have a characteristic whorled pattern

24
Q

ID

A

Leiomyoma (orange ellipses)
Leiomyosarcoma (yellow circle)

25
ID
Leiomyoma ## Footnote bundles of uniform smooth muscle cells. They have long, slender nuclei and mitotic figures are scarce
26
What is 1 Mesenchymal Uterine Malignancy
Leiomyosarcoma
27
**ID**
Leiomyosarcoma
28
What are the three most common hematogenous metastatic sites for Leiomyosarcoma?
* Lungs * Bone * Brain
29
What are 2 benign uterine mass-forming lesions
* Endometrial Polyp * Leiomyoma

E 1.2: Histology, Anatomy, Pathology, and Infectious Diseases Lab (46 decks)

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