Week 9: Biphasic Breast Masses Flashcards
What are 3 biphasic breast lesions?
- Fibroadenoma
- Phyllodes Tumor
- Gynecomastia
ID
Fibroadenoma
Grossly, a rubbery, white, well-circumscribed
mass
ID
Fibroadenoma
Grossly, a rubbery, white, well-circumscribed mass that is hormonally responsive and grows during pregancy and regress after menopause
ID
Fibroadenoma
ID
Fibroadenoma
The proliferation of intralobular stroma surrounds, pushes, and distorts the associated epithelium
ID
Fibroadenoma
The proliferation of intralobular stroma surrounds, pushes, and distorts the associated epithelium
What mutation is associated with Fibroadenomas of the breast?
MED12 exon 2 somatic mutations
The most important cause of hyperestrinism in assigned male at birth (AMAB) individuals is?
Cirrhosis
liver metabolizez estrogen
4 most common endogenous causes of gynecomastia
- Cirrhosis
- Testosterone dropping with aging
- Klinefelter Syndrome (XXY karyotype)
- Testicular Tumors
ID
Gynecomastia
Increased Intralobular stroma (curved black arrows) and presence of mild epithelial hyperplasia with lobules (open black arrows)
2 most common exogenous causes of gynecomastia
- Alcohol
- Drugs (Spironolactone and Risperidone)
ID
Phyllodes Tumor
leaf-like architecture and high stroma to epithelial ratio
ID
Phyllodes Tumor
leaf-like architecture emphasized
ID
Phyllodes Tumor
high stroma to epithelial ratio emphasized
ID
Phyllodes Tumor
