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Histology, Anatomy, Pathology, and Infectious Diseases Lab > Week 9: Renal Neoplasms > Flashcards

Week 9: Renal Neoplasms Flashcards

1
Q

ID

A

angiomyolipoma

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2
Q

ID

A

angiomyolipoma

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3
Q

What is the genetics for angiomyolipoma

A

Tuberous sclerosis 1/2 gene (TSC1 or TSC2)

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4
Q

ID

A

Papillary Adenoma - note normal glomeruli

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5
Q

ID

A

Papillary Adenoma

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6
Q

ID

A

Oncocytoma - mahongany brown with central stellate scar

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7
Q

ID

A

Oncocytoma - nests of eosinophilic granular cytoplasm, round nuclei, and nucleoli present

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8
Q

ID

A

Oncocytoma - EM you see all the mitochondria present

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9
Q

ID

A

Clear Cell Renal Carcinoma

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10
Q

ID

A

Clear Cell Renal Carcinoma - accumulation of lipid in tumor why it is yellow (fat stains clear)

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11
Q

What is the major risk factor for Clear Cell Renal Carcinoma

A

tobacco smoking

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12
Q

What genetic mutation leads to Clear Cell Renal Carcinoma

A

VHL inactivation (Chromosome 3)

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13
Q

What is the inheritence pattern for Von Hippel-Lindau (VHL) Syndrome?

A

Autosomal Dominant

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14
Q

What presentation is indicative of VHL Syndrome

A

bilateral/multifocal Clear Cell Renal Carcinoma

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15
Q

What is VHL responsible for

A

tumor supressor protein that acts on hypoxia-induced transcription factors (HIF)

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16
Q

ID

A

Papillary Renal Cell Carcinoma

17
Q

ID

A

Papillary Renal Cell Carcinoma - encapsulated

18
Q

ID

A

Papillary Renal Cell Carcinoma - foamy macrophages and psamommatous calcifications

19
Q

What is the genetics for Papillary Renal Cell Carcinoma

A

Autosomal Dominant MET oncogene activation

20
Q

ID

A

Chromophobe Renal Cell Carcinoma

21
Q

ID

A

Chromophobe Renal Cell Carcinoma - binucleated cells with halos and “raisinoid” nuclei

22
Q

ID

A

Chromophobe Renal Cell Carcinoma

23
Q

ID the similar conditions

A

Chromophobe Renal Cell Carcinoma and Oncocytoma

24
Q

What is the genetics for Chromophobe Renal Cell Carcinoma

A

Autosomal Dominant Birt-Hogg-Dube (BHD) mutation

Histology, Anatomy, Pathology, and Infectious Diseases Lab (29 decks)

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