Lab 2: Lymphomas Flashcards

1
Q

ID

A

Hodkin Lymphoma; Reed-Sternberg cells

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2
Q

What cell markers do you see with Hodkin Lymphoma?

A
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3
Q

ID

A

Follicular Lymphoma

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4
Q

What translocation is present in Follicular Lymphoma

A

t(14;18) IgH and anti-apoptotic BCL-2

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5
Q

is anti-apoptotic and proto-oncogene indolent or aggressive?

A

anti-apoptotic are indolent
proto-oncogene are aggressive

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6
Q

ID

A

Small Lymphocytic Lymphoma

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7
Q

What cell markers do you see with Small Lymphocytic Lymphoma

A
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8
Q

is Small Lymphocytic Lymphoma indolent or aggressive

A

indolent

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9
Q

What causes Small Lymphocytic Lymphoma to develop to Diffuse-Large B-Cell Lymphoma (DLBCL)

A

Richter transformation; also happens with Chronic Lymphocytic Leukemia (CLL)

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10
Q

ID

A

Diffuse-Large B-Cell Lymphoma (DLBCL)

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11
Q

What cell markers do you see with Diffuse-Large B-Cell Lymphoma (DLBCL)

A
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12
Q

ID

A
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13
Q

ID

A

Burkitt Lymphoma

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14
Q

What translocation is present in Burkitt Lymphoma

A

t(8;14) c-MYC and IgH

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15
Q

What is seen in endemic versus sporadic Burkitt Lymphoma

A

Endemic - jaw mass linked with EBV
Sporadic - mass in ileocecum and peritoneum

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16
Q

ID

A

Mantle-Cell Lymphoma

17
Q

What translocation is present in Mantle-Cell Lymphoma

A

t(11;14) cyclin D1 and IgH

18
Q

What cell markers do you see with Mantle-Cell Lymphoma

A
19
Q

ID

A

Plasma Cell Myeloma (Multiple Myeloma)

20
Q

What are the symptoms for Plasma Cell Myeloma (Multiple Myeloma)

A

CRAB:
Calcemia (hyper)
Renal Dysfunction
Anemia
Bony lytic lesions

21
Q

What do you see with RBCs in Plasma Cell Myeloma (Multiple Myeloma)

A

Rouleaux formation (coin stacking)

22
Q

ID MGUS in terms of M spike, clonal plasma cells, and CRAB symptoms

A
23
Q

ID Smoldering Myeloma in terms of M spike, clonal plasma cells, and CRAB symptoms

A
24
Q

ID Multiple Myeloma in terms of M spike, clonal plasma cells, and CRAB symptoms

A
25
Q

ID

A

Bony Lytic Lesions

26
Q

ID

A

M-spike

27
Q

ID the staging

A