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E 1.1: Histology, Anatomy, Pathology, and Infectious Diseases Lab > Lab 2: Leukemia and Mimics > Flashcards

Lab 2: Leukemia and Mimics Flashcards

1
Q

ID

A

Normal bone marrow biopsy

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2
Q

What causes too few cells (cytopenias)

A

Decreased production or increased destruction

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3
Q

What causes too many cells (cytosis)

A

Increased production

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4
Q

What is a relative versus absolute increase/decrease

A

Relative - proportion is higher/lower than normal
absolute - total number is higher/lower than normal

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5
Q

Major adverse consequence of neutropenia

A

Susceptible to bacterial and fungal infections

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6
Q

What determines acute versus chronic leukemia?

A

Acute if blasts are greater than 20%
Chronic blasts are less than 20%

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7
Q

ID

A

Döhle bodies; leukemoid reaction with toxic granulation

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8
Q

ID

A

Reactive lymphocytes - abundant cytoplasm, small vacuoles, and oval dented nuclei

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9
Q

Tumor cells mostly in
bone marrow and blood.
Lymphoid or myeloid
cells

A

Leukemia

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10
Q

Tumor cells mostly in
lymph node/tissue.
Lymphoid cells, by
definition

A

Lymphoma

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11
Q

Neoplastic Proliferation of WBC includes what origins

A

Lymphoid, Myeloid, and Histiocytes

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12
Q

What cells are lymphoid origin

A

B-cells, T-cells, NK-cells, and Plasma cells

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13
Q

What cells are Myeloid origin

A

Erythroid, thrombocytic, and Granulocytic

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14
Q

What cells are Histiocytic origin

A

Macrophages and Dendrites

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15
Q

ID

A

Auer rod in myeloblast (AML / APL)

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16
Q

CD (Cluster Differential) below 10 is usually indicative of what lineage

A

T cell

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17
Q

CD (Cluster Differential) above 10 is usually indicative of what lineage

A

B-cell

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18
Q

Rituximab usually targets what

A

CD20

19
Q

ID

A

Leukemoid reaction

20
Q

ID

A

Chronic Myeloid Leukemia (CML)

21
Q

ID

A

Chronic Myeloid Leukemia (CML)

22
Q

ID

A

Chronic Myeloid Leukemia (CML)

23
Q

What translocation is associated with CML?

A

t(9;22) ABL-BCR fusion tyrosine kinase

24
Q

What is the treatment for CML?

A

Imatinib

25
Q

ID

A

Chronic Lymphocytic Leukemia (CLL)

26
Q

ID and cell you see

A

Chronic Lymphocytic Leukemia (CLL); soccer ball/cookie cells lymphocytes and Smudge cells

27
Q

What imune-mediated hemolytic anemia do you see in Chronic Lymphocytic Leukemia (CLL)

A

warm

28
Q

What is the most common leukemia in adults

A

Chronic Lymphocytic Leukemia (CLL)

29
Q

ID blue cells

A

CD5 and CD20+ and Kappa chain +; CLL

30
Q

ID

A

Acute promyelocytic leukemia (APL)

31
Q

ID

A

Acute promyelocytic leukemia (APL)

32
Q

What translocation is associated with APL?

A

t(15;17) PML-RAR alpha fusion/ MPO+

33
Q

What translocations and cell markers do you see with APL

A
34
Q

What do you treat APL with?

A
35
Q

ID

A

B-cell Acute Lymphoblastic Leukemia (B-ALL)

36
Q

ID

A

B-cell Acute Lymphoblastic Leukemia (B-ALL)

37
Q

What cell markers do you see with B-ALL

A
38
Q

most common complication of B-cell Acute Lymphoblastic Leukemia (B-ALL)

A

spreading to nervous sytem

39
Q

ID

A

Epstein-Barr Infection (EBV)

40
Q

ID

A

Epstein-Barr Infection (EBV); indented nucleus and abundant cytoplasm

41
Q

What test result is positive in Epstein-Barr Infection (EBV)

A
42
Q

ID- EPO levels are low

A

Polycythemia Vera (PCV)

43
Q

ID

A

Essential Thrombocythemia - lots of platelets with varying sizes

44
Q

ID

A

Primary Myelofibrosis - dacryocytes present

E 1.1: Histology, Anatomy, Pathology, and Infectious Diseases Lab (29 decks)

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