Week 8 Auditory and Vestibular Systems Flashcards

1
Q

Give an overview of the central auditory pathway.

A
  • sound waves creates a wave the travels down scala vestibule. Displaces basement membrane and activates hair cell in organ of corgi. Hair cell movements generate action potentials in CN VIII
  • signal from cochlea to the CNS
  • auditory system analyzes frequency, volume, location of sound
  • neuron chain is formed to the auditory cortex in temporal lobe
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2
Q

What is neuron 1 of the auditory pathway?

A
  • Cell bodies of bipolar neurons of cochlear ganglion in inner ear
  • dendrite contact hair cells in organ of corti, axons form cochlear part of CN VIII
  • CN VIII travels through petrous part of temporal bone, enters through internal acoustic meatus
  • to brain stem at pontomedullary junction at cerebellopontine angle lateral to CN VII
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3
Q

Where are the nuclei of neuron 2 of the auditory pathway?

A
  • in dorsal and ventral cochlear nuclei in the medulla at the pontomedullary junction
  • nuclei are wrapped around ICP
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4
Q

What is the path of axons of neuron 2 in the auditory pathway?

A
  • axons decussate in lower pons to contralateral side at trapezoid body
  • ascent in lateral lemniscus (LL) to inferior colliculus in caudal midbrain
  • many nuclei along pathway that contributes to LL axons
  • multisynaptic and bilateral system
  • LL synapses in inferior colliculus and ascends to medial geniculate nuc. of thalamus (MGN) bilaterally
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5
Q

After axons synapses at MGN of thalamus, what pathway does it take in the auditory pathway?

A
  • pass through sublentiform part of posterior limb of internal capsule and end in primary auditory cortex (Hershel’s gyrus)
  • each auditory cortex receives from both ears, but input from contralateral side is greater
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6
Q

What would result from a unilateral lesion in the auditory pathway after the cochlear nuclei?

A
  • unilateral lesions after the cochlear nuclei don’t result in significant hearing loss, some diminution of hearing in contralateral ear
  • most hearing problems most likely occur in external, middle, inner ear and to auditory nerve itself (hearing problem is ipsilateral to lesion)
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7
Q

What are examples of conduction deafness and sensorineural deafness?

A
  • conduction: wax, ruptured tympanic membrane, fluid in middle ear, otosclerosis
  • sensorineural deafness: damage to organ of corgi, auditory nerve along its course until it enters brainstem. E.g. vestibular schwannoma compressing VIII nerve, aging, drugs
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8
Q

What is neuron 1 in the vestibular pathway?

A
  • cell bodies of bipolar neurons of vestibular ganglion

- dendrites contact vestibular receptors in membranous labyrinth and axons converge to form vestibular part of VIII

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9
Q

What is neuron 2 in the vestibular pathway?

A
  • most axons synapse in vestibular nuclei, but some enter vestibulocerebellum via ICP
  • vestibular nuclear compex occupies area of floor of IV ventricle at lateral angle, partly in medulla, and partly in pons
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10
Q

How do axons of the vestibular nuclei connect with nuclei of EOM, LMNs, and vestibulocerebellum?

A
  • medial longitudinal fasciculus (MLF) to control eye movements
  • lateral and medial vestibulospinal tracts to LMNs: from vestibular nuclei synapse on LMNs to help maintain balance during changes in head position and movements by adjusting tone in neck, trunk and limb muscles. (lateral-all levels of cord, medial-cervical cord only)
  • ICP to vestibulocerebellum: bidirection axons from vestibular nuclei to flocculonodular lobe to coordinate eye movements & balance in response to changes in head position and movement
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11
Q

Describe the vestibulo-ocular reflex (VOR) that occurs when turning head to left.

A

-turning head to left stimulates left vestibular nuclei (ipsilateral)
-axons from left nuclei synapses on right VI nucleus
–>activates lateral rectus on right side
–>VI via MLF activates left CN III nucleus to contract medial rectus
(part of PPRF pathway)
-result: slow conjugate eye to right in response to head rotation to left
(normal individuals: cortex suppresses VOR)

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12
Q

What will result from caloric stimulation with cold water to the right ear?

A

Slow: eyes to same side as cold water, fast: eyes to opposite side

  • pushes endolymph away from ampulla, decreasing firing rate
  • activates vestibular nuclei on left (opposite side)
  • left nuclei activates right CN VI: lateral rectus, and left CN III: medial rectus
  • slow movement to right
  • fast movement (nystagmus) to left
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13
Q

What will result from caloric stimulation with warm water to the left ear?

A

slow: eyes move to opposite side as warm water, fast: eyes move to same side
- pushes endolymph towards ampulla, and increases firing rate
- activates vestibular nuclei on same side, which activates opposite CN VI nuclei (right)
- slow movement to right
- fast movement to the left

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14
Q

What are 3 types of nystagmus that can be elicited in the normal individual? (physiological response)

A
  1. Optokinetic-when you follow a target across the visual field and then quickly rerun to starting point (watching telephones poles in a car)
  2. oculocephalic reflex-Rotary nystagmus: quick rotation of head with slow phase of eye movement in opposite direction and fast back
  3. caloric stimulation: using hot or cold water irrigation in ear to cause endolymph to move
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15
Q

What are pathological causes of nystagmus?

A
  • congenital
  • vestibular-damage to semicircular canal
  • central-due to disease of brainstem or cerebellum
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16
Q

Turning the head to the left has the same effect as:

A
Turning the head to the left
 = cold water in the right ear 
= warm water in the left ear
= Damage to the right  vestibular sensory organs/Vestibular nerve/nu.
= Nystagmus to the left
17
Q

Turning the head to the right has the same effect as:

A
Turning the head to the right
 = cold water in the left ear 
= warm water in the right ear
 = Damage to the left  vestibular sensory organs/Vestibular nerve/nu.
= Nystagmus to the right
18
Q

How can the oculocephalic reflex in an unconscious person be tested?

A

Turning head to either side with eyes held open

  • intact brain stem: “doll’s eyes”, slow eye movements to opposite side to head turning. No nystagmus in unconscious person
  • bilateral stem stem damage: absent reflex, eyes will look straight ahead-signals lower brain stem lesion and ensuing respiratory and cardiovascular function loss
  • can be verified with stronger stimulus, such as caloric testing