Week 3 Motor Pathways Flashcards

1
Q

Where are the lower motor neurons of the neck, trunk, and limbs found? What about for the head?

A
  1. in the spinal cord
    - neurons that control the proximal muscles are medial in the ventral horn
    - neurons that control distal muscles are lateral
  2. Cranial nerve nuclei in the brain stem
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2
Q

Where are the upper motor neurons located?

A
motor cortex (primary motor cortex and FEF) and subcortical nuclei
-neurons of corticospinal and corticobulbar are largely found in pre central gyrus and paracentral lobule
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3
Q

Where do the planning and programming of motor activity occur?

A
  1. supplementary motor area (SMA)- located on medial surface of frontal lobe anterior to paracentral lobule
  2. Premotor area (PMA)- located lateral to the SMA and anterior to the primary motor cortex
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4
Q

Describe the somatotopic arrangement and course of the corticospinal tract.

A

-Posterior limb of internal capsule: upper limb anterior to those for lower limb
-midbrain: passes through middle 3/5s of crus cerebri. Upper limb fibers more medial to lower limb
-Pons: passes the ventral part of pons, despised among pontine nuclei.
-medulla: axons in upper medulla form pyramid. 75-90% of axons cross at junction of medulla and spinal cord
-spinal cord:
Lateral corticospinal tract: cross over, they follow this tract in the lateral funiculus
anterior: some cross over and some don’t, they follow the ACST in ventral funiculus and end bilaterally

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5
Q

Where are the cranial nerves with somatomotor components located?

A
CN III: upper midbrain
CN IV: lower midbrain
CN V: mid pons
CN VI: lower pons
CN VII: lower pons
CN IX and X: upper medulla
CN XI: upper 5-6 segments of spinal cord
CN XII: upper medulla
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6
Q

Describe the origin and course of the corticobulbar tracts.

A

-origin: Primary motor cortex close to lateral sulcus (also from PMA, SMA, general sensory cortex, sensory assoc areas)
-corona radiata: mixed with CST
-internal capsule: at genu of posterior limb, anterior to CST
-midbrain: media to CST fibers
-pons and pyramid: mixed with CST and indistinguishable
Axons leave Corticobulbar tract at level of cranial motor nuclei

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7
Q

Corticobular tracts for which cranial nerve nuclei end bilaterally?

A

CN V: medially at middle 1/3rd of pons
CN IX and X: nucleus ambiguus
CN XI: C2-C5 levels

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8
Q

Corticobular tracts for which cranial nerve nuclei end contralaterally?

A
CN XII (actually bilateral but contralateral input predominates)
-in the upper medulla
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9
Q

Corticobular tracts for which cranial nerve nuclei end bi- and contra laterally? Describe it.

A

CN 7 facial nerve

  • upper group of neurons innervates upper facial muscles
  • Bilaterally: LMNs that innervate upper face
  • Contralateral: LMNs that innervate lower face
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10
Q

A UMN lesion anywhere along the corticobulbar tract of CN VII will result in what?

A
  • normal upper face due to bilateral sparing (can wrinkle forehead)
  • contralateral lower facial paralysis
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11
Q

What will a LMN lesion along the coriticobulbar tract of CNVII cause?

A

Bell’s palsy

-paralysis of entire half of face ipsilateral to lesion

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12
Q

What do UMN lesions of the corticobulbar tract of CN XII result in?

A

contralateral tongue weakness

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13
Q

What do LMN lesions of the corticobulbar tract of CN XII result in?

A

Ipsilateral tongue weakness

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14
Q

What are corticospinal tracts essential for?

A
  • voluntary control of contralateral skeletal muscles of neck, trunk, and limbs.
  • voluntary activity in response to sensory
  • rapid finely coordinated movements
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15
Q

What are corticobulbar tracts essential for?

A

-voluntary contractions of the muscles of the head by V, VII, IX, X, XI, XII

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16
Q

What are UMN pathways from brain stem centers for?

A

regulate motor activity, mainly of non skilled variety e.g. postural adjustments, locomotion, stabilization of proximal joints

17
Q

Describe the pathways for saccades in the horizontal plane for conjugate eye movements.

A

-motor commands from frontal eye fields (FEF) in posterior part of middle frontal gyrus
-ill defined pathway to reach the pons
-axons cross and end on paramedic pontine reticular formation (PPRF)
For CN VI
-axons sent to VI nucleus then to VI nerve to innervate lateral rectus on same side (opposite of origin)
For CN 3
-axons cross to other side to medial longitudinal fascicles (MLF) to reach III nucleus to III nerve to innervate medial rectus (same side as origin)

18
Q

Unilateral brain stem lesion at the level of the pons that involve the pPRF and the VI nucleus will result in an inability to move the eye to which side?

A

-side of the lesion

19
Q

what does the demyelination of MLF, as can occur in MS, result in?

A

-failure of ipsilateral eye to adduct as contralateral eye abducts

20
Q

What may a LMN lesion involve?

A
  • anterior horn cells
  • brain stem cranial nerve motor nuclei
  • dorsal or ventral rami
  • peripheral nerves
  • cranial nerves
21
Q

What signs and symptoms characterize a LMN syndrome?

A
  • paresis or paralysis
  • flaccidity
  • loss of deep tendon reflexes
  • muscle atropy
  • fasciculations
22
Q

What are the signs and symptoms of UMN lesions?

A
  • loss of strength and voluntary movements-contralateral side
  • small lesions likely to deprive a large # of LMNs of their control–>hemiplegia, paraplegia, monoplegia
  • paralysis predominately affecting distal parts
  • hyperreflexia- exaggerated DTRs
  • increased tone–>spasticity
  • absence of profound muscular atrophy
  • abnormal babinski sign
  • abnormal posturing
23
Q

What are the two major types of conjugate eye movements?

A
  1. saccades: rapid movements that redirect gaze

2. smooth pursuit movements- tracking moving object to allow stable viewing of object in motion

24
Q

Compare LMN and UMN lesions with respect to weakness, atrophy, fasiculations, reflexes, tone

A
Weakness: Both
atrophy: LMN only
fasciculations: LMN only
reflexes: increased in UMN, decreased in LMN
Tone: increased in UMN, decreased in LMN
25
Q

Compare LMN and UMN lesions with respect to weakness, atrophy, fasiculations, reflexes, tone

A
Weakness: Both
atrophy: LMN only
fasciculations: LMN only
reflexes: increased in UMN, decreased in LMN
Tone: increased in UMN, decreased in LMN