week 7-Treatment approaches for drug addiction Flashcards
General approaches to support who are recovering from drugs are to give ____ ____, use ____ ____, blocking the ____, and ____
social support; substitution therapy; reward; exercise
Substitution therapies for opioid abusers involve using ____ or ____
methadone; buprenorphine
____ is a mu opioid ____, one that is difficult to wean yourself off, dependent on the clinic that’s administering it, and there is also the potential for abuse. This one is for someone who is severe addicts
Methadone; agonist
____ is a mixed (mu kappa delta) partial opioid ____, one that is easier to wean yourself off, can take as pills, and there is less potential for abuse than the other substitution therapeutic drug
Buprenorphine; agonist
____ ____ have both agonistic and antagonistic effects – when both a full ____ (eg. heroin) and ____ _____ (burenorphine) are present, it actually acts as a competitive ____, competing with the full ____ for receptor occupancy and produce a net ____ in the receptor activation observed with the full ____ alone.
Partical agonists; agonist; partial agonist; antagonist; agonist; decrease; agonist
Suboxone is a combination drug formulation of ____ and ____ in a 4:1 ratio for treating ____ dependence. ____ is similar to naltrexone, which is a mu opioid ____. When taken ____ as intended, ____ does not get absorbed, but if taken intravenous it produces dysphoria and prevents abuse.
buprenorphine; naloxone; opioid; Naloxone; antagonist; orally; naloxone
____ is a drug that treats alcoholism that works through blocking ALDH conversion of ____ to ____ ____, resulting in accumulation of ____ toxin in the blood.
Antabuse; acetaldehyde; acetic acid; acetaldehyde
Metabolization of alcohol in the body:
1. Alcohol converted to ____ by ____ ____ (ADH)
2. ____ converted to ____ ____ by ____ ____ (ALDH)
3. ____ ____ can then be discharged with CO2 and water
- acetaldehyde; alcohol dehydrogenase
- acetaldehyde; acetic acid; aldehyde dehydrogenase
- acetic acid
Wheel running experiment paired with cocaine
Running ____ conditioning facilitates ____ of conditioned place preference for ____ compared to sedentary mice (sustained preference)
after; extinction; cocaine
Wheel running experiment paired with cocaine
Running ____ conditioning delays ____ of conditioned place preference for ____, which can be problematic for people wanting to quit.
before; extinction; cocaine
Wheel running experiment paired with cocaine
Conditioning before exercise, then relapse: How did the mice do?
A single conditioning trial after running reverse the benefit of exercise on facilitating extinction of CPP – exercise no longer has an effect
Effects of exercise on conditioned place preference for ____ depends on when the running is administered relative to the conditioning and testing. If exercise is administered ____ conditioning it can facilitate extinction, but if it comes ____ conditioning, it delays extinction.
cocaine; after; before
We can use ____ and ____ to block the reward for treating addiction
naltrexone; antabuse
(both mostly for alcohol)
