Week 5 - Muscular system Flashcards
Identify and explain the differences of the three types of muscle in the human body Describe the functions of skeletal muscle Identify and describe the anatomy of a skeletal muscle Explain the stages of the sliding filament theory Explain a what a motor unit is Explain the role of calcium and ATP in muscular contraction Explain the excitation-contraction coupling mechanism Acknowledge the differing fibre types
Primary function of the muscular system
Produce movement in the body
Other functions of the muscular system
▪ Constriction of organs and vessels ▪ Cardiac contraction ▪ Respiration ▪ Postural maintenance ▪ Body heat production
3 types of muscle
Smooth muscle, cardiac muscle, skeletal muscle
2 striated muscle types
Skeletal and cardiac
2 involuntary muscle types
Cardiac and smooth
4 building blocks of muscle, largest to smallest
Muscle fascicle, muscle fiber, myofibril, myofilaments
What is a section of a myofibril called
sarcomere
3 layers of skeletal muscle connective tissue layers
Epimysium (surrounds muscle), perimysium (surrounds muscle fiber bundle), endomysium (surrounds muscle fiber)
Skeletal muscle organelles (6)
Sarcolemma, sarcoplasmic reticulum, transverse tubule, sarcoplasm, mitochondria, nucleus
Sarcolemma location and function
Location: On the cell membrane of muscle, fuses with tendon which fuses with bone
Function: Assists with action potentials along muscle, transports metabolites in and out of cell
Sarcoplasmic reticulum location and function
Location: Network of tubules run along and around myofibrils
Function: storage site for calcium
Transverse tubules location and function
Location: Extension of sarcolemma that pass laterally through cell
Function: Allow action potentials to be transmitted into the myofribrils
Names of fast and slow twitch muscle fibers
Slow - Type 1 (slow oxidative fibers) (SO)
Fast - Type 2a (fast oxidative glycolytic fibers) (FOG)
&
Type 2b (Fast glycolytic fibers) (FG)
What colour are Type 2a muscle fibers and why
White as they don’t need oxygen-rich blood to create fast energy
Sliding filament model/theory
Interaction of myofilaments cause muscle contraction and shortening
Myosin
Thick filaments are bundles of myosin molecules
What does each globular head of myosin have
Myosin ATPase site and an Actin binding site
Actin
Thin filaments are paried chains of actin molecules each with a myosin binding site
Brown strands that wrap around Actin
Tropomyosin
Troponin
Holds tropomyosin in place
What prevents myosin from binding to the myosin binding sites on actin
Tropomyosin covers the binding sites and troponin holds tropomyosin in place
What is the key to unlock troponin
Calcium
Where is calcium stores in the muscle
Sarcoplasmic reticulum
Cross-bridge
Attachment of myosin to Actin
What is the energy molecule in the body?
Adenosine Triphosphate (ATP)
ATP turns into what when ATPase comes along
Adenosine Diphosphate (ADP) + Energy
Stages of sliding filament theory
- Exposure of Active sites
- Cross-Bridge formation
- Power stroke
- Cross-Bridge release
- ATP to ADP and P
- Recovery stroke
Cross bridge cycling will occur again if Calcium is still connected to troponin
Without ATP what occurs and an example
Myosin and actin remain bound
In rigor mortis, the muscles stiffen because there is no ATP to release the bond
Functions that require ATP within the muscle
Power stroke
Release of myosin from actin after power stroke
Transporting calcium back to sarcoplasmic reticulum