Week 5 - AA Metabolites

Question 0

Which of the following is most likely to cause inflammation?

Answer 0

PGE2 - Prostaglandins

A tiny bit- Leukotrienes - related to asthma

Question 1

Which enzyme is most likely to release AA from membrane?

Answer 1

Phospholipase A2 (followed much later by Phospholipase C)

Question 2

What is most likely to cause an MI (myocardial infarction)?

Answer 2

Thromboxane A2 (causes clot) - promotes MI

Prostacyclin –> protects you against clots - prevents MI

Question 3

COX 2 Inhibitors primarily block AA metabolism in endothelial cells to cause myocardial infarction. The synthesis of which of the following products is inhibited most:

Answer 3

Prostacyclin

Question 4

What agents block cyclooxygenase and treat arthritis symptoms?

Answer 4

Ibuprofen, Naproxen, Celebrex

Question 5

What pathway causes inflammation?

Answer 5

Arachidonic acid is produced which causes PGE2 to be produced which causes inflammation.

Question 6

Which of the following suppresses both prostaglandin and leukotriene synthesis?

Answer 6

Prednisone - blocks both pathways

Question 7

Which of the following selectively prevents leukotriene synthesis?

Answer 7

Zafirlukast & Zileuton

Question 8

Which of the following relieves arthritis symptoms by reversibly blocking prostaglandin synthesis?

Answer 8

Ibuprofen

Question 9

Which of the following both relieves arthritis symptoms and reduces risk of MI?

Answer 9

Acetylsalicylic acid (aspirin)

Question 10

Which of the following is an effective arthritis treatment with the least risk of gastric ulceration?

Answer 10

Celecoxib (Celebrex)