Week 3 - Immune System Overview Flashcards

0
Q

What TLRs detect Bacterial Infections?

A

TLR4- LPS (gram negative)

TLR5 - Flagellins

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1
Q

What are the 3 basic layers of the immune system?

A
  1. Physical Layer
  2. Innate Immune System
  3. Adaptive Immune System
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2
Q

What TLRs detect Viral Infections?

A

TLR9 - CpGRNA
TLR13 - dsRNA
(in an endosome)

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3
Q

What is the stratum corneum?

A

It is made up of dead cells/terminally differentiated/Non-living keratinocytes.

  • Make up protective layer of skin
  • Cells dry, regenerate, dec. pH, inc. salt
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4
Q

What does IL-2 do?

A

Proliferative - drives T cells to grow & divide

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5
Q

What does IL-12 do?

A

T cell differentiation to Th1

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6
Q

What does IL-4 do?

A

T cell differentiation to Th2

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7
Q

What are INF-gamma and TNF-beta?

A

Proinflammatory - Th1

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8
Q

What does IL-4 and IL-5 do?

A
It helps activate eosinophils & mast cells: force class switch maturation (to IgE) [Th2] 
-When class switch is done inappropriately, it causes hay fever
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