Week 3 - Case 1 Flashcards

0
Q

What causes SSSS and what does SSSS stand for?

A

Staphylococcal Scalded Skin Syndrome

-It’s cause by Staphylococcus aureus and a previous systemic infection

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1
Q

What does VINDICATE stand for?

A
Vascular
Infection (viral, bacterial, fungal)
Neoplasm
Drugs (medications or illicit drugs)
Inflammatory/Idiopathic
Congenital
Autoimmune
Trauma
Endocrine/Metabolic
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2
Q

What does a typical SSSS case involve?

A

Ill child for the past few weeks, runny nose, not eating well, generalized rash, red eyes, red tounge, slightly inflamed throat, a few large cervical lymph nodes

  • General erythematous rash present with exfoliation on the face, back of the neck, ears and feet (red, flaking skin)
  • Do a skin culture to confirm your diagnosis
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3
Q

What is childhood exanthema?

A

A skin rash accompanying a disease or fever

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4
Q

What are possible causes of Childhood Exanthema?

A
  1. Viral Exanthemas
  2. Scarlet fever
  3. Thermal burns
  4. Pemphigus
  5. Kawasaki disease
  6. SSSS
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5
Q

What is associated with the chicken pox virus?

A

Varicella zoster - prodrome of fever and malaise
-Rash with blisters followed by scabs on body and head
Diagnosis: can culture lesions but most diagnosis made by history and exam

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6
Q

What causes fifths disease?

A

This is also “slapped cheeks” syndrome caused by Parvovirus B19.
-It is associated with fever and joint pain.
Diagnosis is done by history and exam, no lab.

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7
Q

What is pemphigus? What does this disease create antibodies against?

A

-Blistering, autoimmune disease
-Autoantibodies against desmoglein, which glues epidermal cells together
Diagnosis: Skin punch biopsy

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8
Q

What organism causes scarlet fever and how does the disease progress?

A
Group A strep
-Begins with fever and sore throat
-Rash begins on neck and chest
-Red tongue with white patch on back of tongue
Diagnosis: throat swab for strep antigen
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9
Q

What does Kawasaki disease cause and how is it diagnosed?

A

-Autoimmune vasculitis
-Affects skin, mucous membrane, blood vessels and heart
-High fever and rash, red eyes, enlarged lymph nodes
Diagnosis: history and physical only, no lab that helps

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10
Q

SSSS - what does the gram stain look like?

A

Gram +, purple, cocci in clusters/clumps

Staphylococcus aureus

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11
Q

What is a diagnostic test to determine if an organism is SSSS? What toxins does SSSS produce?

A
The staph should be coagulase positive.
Releases exfoliatin (epidermolysin), an extracellular toxin
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12
Q

What is the typical presentation of SSSS?

A

-Erythematous rash near eyes and mouth, red eyes (conjunctiva), exfoliation of skin
-Can occur in newborns or babies
-Starts as skin redness followed by exfoliation of skin 2-5 days later
-Typically associated with fever
Diagnosis: based on history and appearance
Lab test: CRP increased, platelet count normal, Grams stain positive, blood or tissue cultures will confirm the diagnosis later

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13
Q

What does the exfoliatin toxin do?

A

It splits the upper epidermis below the granular cell layer.

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14
Q

How to treat SSSS?

A
  • Beta-lactamase resistant Penicillin (ampicillin/sulbactam) or Penicillinase-resistant penicillin (Nafcillin)
  • Isolate the child - easily transmitted
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15
Q

What is the mortality for SSSS?

A

50% in adults

3-10% in children