Week 3 Nervous system Flashcards

1
Q

What are the two different types of cells Nervous tissue is made up of:

A

neurons and glial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

A neurons function is to :

A

Communicate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Neurons are found in the :

A

CNS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the different types of neurons:

A

sensory, motor, and interneurons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Glial cells function are :

A

they are the supporting tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the various types of glial cells?

A

Astrocytes, Oligodendrocytes, Ependymal, Microglia, Satellite cells, Schwann cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Where are glial cells found?

A

some in CNS and some in PNS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Oligodendrocyte:

A

(CNS), Myelinate CNS axons, provide structural framework

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Astrocyte:

A

(CNS)Maintain blood brain barrier, structural support, regulates ion, nutrients, and dissolved gas concentrations, absorbs and recycle neuronstransmitters, FORMS SCAR TISSUE AFTER INJURY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Ganglia:

A

Neuronal cell bodies outside of the CNS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Ependymal Cells:

A

(CNS) lines ventricles (brain) and central canal (spinal cord), assists in producing CSF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Microglia:

A

(CNS) removes cell debris, wastes, and pathogens by phagocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Satellite cells:

A

(PNS) surrounds neuron cell bodies in ganglia, regulates O2, CO2, nutrients and neurotransmitter levels around neurons in ganglia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Schwann cells:

A

(PNS) are responsible for myelination of peripheral axons in PNS, enclosed in the myelin sheath, participates in repair process after injury

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Myelin sheath :

A

fatty substance covering the axon, forms in sections, produced by Oligodendrocyte (CNS) & Schwann cells (PNS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Unmyelinated sections are called :

A

Node of Ranvier

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what is the function of the myelin sheath, why do we need it?

A

speeds up transmission of electrical signal by enabling saltatory conduction, it also insulates axons, & keeps ions in

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is saltatory conduction?

A

The process in which the electrical signal hops from one node of ranvier to the next node of ranvier, causing the transmission to speed up

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Neurons communicate via ____ ____ and _____ _____.

A

chemical signals and electrical signals.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Chemical signal are called

A

neurotransmitters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Electrical signals are called:

A

action potentials (impulses)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Neurons convert _____ _____ into ______ _____.

A

chemical signals into electrical signals . chemical signal->electrical signal->chemical signal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Chemical signals are located :

A

between neurons, Axon terminal -> synaptic cleft-> Dendrites/Cell body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Electrical signals are located :

A

on neurons, Axon hillock-> Axon body-> Axon terminal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What are the two different classes of neurotransmitters:

A

Excitatory and Inhibitory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What is an excitatory neurotransmitter?

A

Excites the neuron thereby causing an ELECTRICAL signal to be generated.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What is an inhibitory neurotransmitter ?

A

Inhibits the neuron from firing an ELECTRICAL signal.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Examples of excitatory neurotransmitters:

A

Acetylcholine, Dopamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Examples of inhibitory neurotransmitters:

A

GABA, Serotonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Electrical signals are called ____ _____.

A

Action potentials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

where do action potentials occur?

A

on the axon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

What triggers an action potential ?

A

graded potential

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What do action potentials result in?

A

neurotransmitter release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

what is meaning of resting membrane potential ?

A

Membrane potential of the neuron when it is at rest (not firing any action potentials)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What is the value (mv) of resting membrane potential?

A

-70 mv

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Action potential will only occur when it reaches _____ mv.

A

-50 mv, threshold

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

What is the meaning of threshold?

A

Minimum amount of voltage needed to initiate an action potential

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

How is the membrane able to reach threshold (go from -70mv to -50mv)?

A

Via graded potential

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

What does graded potential do?

A

Triggers an action potential to occur

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

What is a graded potential?

A

Summation of multiple neuronal outputs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

What is depolarizing graded membrane potential?

A

When membrane potential becomes POSITIVE and is taken TOWARDS threshold

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

What is another name for depolarizing graded membrane potential?

A

EPSP (Excitatory post synaptic potential)

43
Q

What causes membrane potential to depolarize?

A

excitatory neurotransmitters

Acetylcholine, Dopamine

44
Q

What is hyperpolarizing

graded membrane potential?

A

When membrane potential becomes negative and is taken away from threshold

45
Q

What is another name for hyperpolarizing graded membrane potential?

A

IPSP (Inhibitory post synaptic potential)

46
Q

What causes hyperpolarizing graded potential?

A

inhibitory neurotransmitters (GABA, Serotonin)

47
Q

What are the two types of graded potential types?

A

Depolarizing & Hyperpolarizing

48
Q

How do depolarizing graded potentials work?

A

Excitatory neurotransmitter is released-> binds to receptor->this opens ligand gated NA+ (sodium) channel->NA+ enters-> membrane becomes positive (taken towards threshold)

49
Q

How do hyperpolarizing graded potentials work?

A

Inhibitory neurotransmitter is released-> binds to receptor-> this opens the ligand gated Cl- (chloride) channel-> Cl- enters-> membrane becomes negative (taken away from threshold, action potential cannot be generated)

50
Q

What are the three phases of an action potential?

A

Depolarization (D, 1st phase),
Repolarization (E, 2nd phase), &
Hyperpolarization (F, 3rd phase)

51
Q

Graded potential occurs on :

A

cell body and dendrites

52
Q

Depolarizing action potential is due to :

A

Opening of Voltage gated sodium Channels and sodium (Na+) enters / influx

53
Q

What is another name for depolarization in action potential?

A

upstroke

54
Q

At what value do the voltage gated Na+ channels close and depolarization end?

A

+30 mv

55
Q

At what value does the depolarization process start in action potential ?

A

-50 mv

56
Q

What is another name for repolarization?

A

downstroke

57
Q

At what value does repolarization start?

A

+30 mv

58
Q

At what value does repolarization end?

A

-70 mv

59
Q

Repolarization is due to :

A

Opening of Voltage gated Potassium Channels and Potassium (K+) exits / efflux

60
Q

Hyperpolarization is due to :

A

Voltage gated Potassium Channels being open due to slow closure and thus more Potassium (K+) continues to exit / efflux

61
Q

At what value does hyperpolarization start?

A

-70 mv

62
Q

At what value does hyperpolarization end?

A

-90 mv

63
Q

How do you bring the membrane of -90mv back to resting membrane potential of -70mv?

A

Sodium potassium pump

64
Q

Action potential will always have the _____ _______.

A

Same appearance

65
Q

What is the all or none phenomenon in action potential

A

Threshold must be reached for an action potential to be generated (no threshold no action potential).

66
Q

what is the self propagating event in action potentials?

A

when the action potential propagates itself from axon hillock down to axon terminal

67
Q

What are the two things that increase the speed of an action potential?

A

increase diameter and increase insulation (more myelin)

68
Q

What are refractory periods in action potentials?

A

resting periods

69
Q

What are the two refractory period types?

A

Absolute Refectory Period & Relative Refractory Period

70
Q

What is absolute refectory period?

A

Another action potential CANNOT be generated regardless of the strength of the stimulus

71
Q

what is relative refectory period?

A

Another Action potential CAN be generated if the stimulus is stronger than the original

72
Q

In what part of action potential is the absolute refractory period in place?

A

Depolarization(D) & Repolarization(E), another action potential cannot be generated during Depolarization and repolarization

73
Q

In what part of action potential is the relative refractory period in place?

A

Hyperpolarization(F), another action potential can be generated during hyperpolarization

74
Q

Why can an action potential be generated in relative refectory period, but not in absolute?

A

In Absolute refectory period, it is because the sodium channels are already open. In relative refectory period, the sodium channels are closed and inactive. The channels can then be forced open w/ a stronger stimulus.

75
Q

synaptic transmission steps

A

action potential arrives at axon terminal->voltage gated Ca2+ (calcium) channels open & Ca2+ enters->Ca2+ enters axon terminal causing the neurotransmitter containing synaptic vesicles to release contents via exocytosis->neurotransmitter diffuses across synaptic cleft and binds to specific receptors on post synaptic membrane

76
Q

What will happen to the postsynaptic membrane once the neurotransmitter binds to it? and what type of graded potential?

A

Graded Potential will be generated. the type of graded potential depends of the type of neurotransmitter released

77
Q

If an excitatory neurotransmitter is released it will bind to a ____ gated ____ channel causing resting membrane potential to move ____ ____.

A

ligand gated sodium channel, towards threshold.

78
Q

If an inhibitory neurotransmitter is released it will bind to a ____ gated ____ channel causing resting membrane potential to move ____ ____ ____.

A

ligand gated chloride channel, away from threshold

79
Q

Excitatory neurotransmitters result in a ______ type of graded potential on the _______ ______.

A

depolarizing, postsynaptic membrane

80
Q

Inhibitory neurotransmitters result in a ______ type of graded potential on the _______ ______.

A

hyper-polarizing, postsynaptic membrane

81
Q

Neurotransmitters are ____ lived.

A

short

82
Q

If neurotransmitters aren’t removed from the synaptic cleft they will ____ to the ___ and cause a change to the _____ _____. (stimulate / inhibit)

A

re-bind, receptors, post synaptic membrane

83
Q

What are the four ways via which the neurotransmitter can be removed?

A

diffusion, phagocytosis, reuptake mechanisms, and enzyme degradation

84
Q

What is diffusion?

A

when the neurotransmitters diffuse out of the synaptic cleft

85
Q

What is phagocytosis?

A

when neurotransmitters are phagocytosed by the WBCs (microglial cell)

86
Q

what is a reuptake mechanism?

A

Presynaptic membrane will take the neurotransmitter back into its terminal
to be repackaged for a new cycle

87
Q

what is Enzyme Degradation ?

A

when an enzyme breaks the neurotransmitter into inactive components

88
Q

The autonomic nervous system is the _____ branch of the PNS.

A

motor

89
Q

The autonomic nervous system regulates _______ ______. (breathing, digestion)

A

unconscious function

90
Q

what are the two subtypes of the autonomic nervous system, they work opposite of each other.

A

Sympathetic & parasympathetic

91
Q

What are the two classes of neurons that work in the autonomic nervous system?

A

preganglionic and postganglionic.

92
Q

Preganglionic neuron starts in the ____ and synapses in the ______.

A

CNS, ganglion

93
Q

Postganglionic neuron starts in the ______ and goes to the ____ _____.

A

ganglion, target organs

94
Q

Sympathetic nervous system is activated when the body senses ____ and increases activity of ___ organs.

A

stress, vital (“fight or flight”)

95
Q

Parasympathetic nervous system is activated when the body is ____ and increases activity of _______ organs.

A

calm, non-vital (“rest & digest”)

96
Q

In the sympathetic nervous system, the ganglions are in the ______ _____.

A

paravertebral chains

97
Q

In the parasympathetic nervous system, the ganglions are in the ______ _____.

A

target organs

98
Q

Preganglionic neurons in the sympathetic nervous system release:

A

acetylcholine

99
Q

Postganglionic neurons in the sympathetic nervous system release:

A

norepinephrine & epinephrine

100
Q

The receptors in the sympathetic system are collectively called the _____ receptors.

A

adrenergic

101
Q

What are the two main classes of adrenergic receptors?

A

Alpha (1,2) & Beta (1,2,3)

102
Q

In the parasympathetic nervous system the preganglionic and postganglionic neurons both release

A

acetylcholine

103
Q

The receptors in the parasympathetic nervous system are collectively called the ______ receptors.

A

cholinergic

104
Q

What are the two main classes of cholinergic receptors?

A

Nicotinic (N,M) & Muscarinic (1,2,3,4,5)