Week 118 Pyrexial Illness

Question 1

What factors do you take into account when choosing an antibiotic?

Answer 1

Likely organisms
Current condition
Previous treatment
Allergies
Patient condition
Age
Pregnant/breastfeeding

Question 2

Name four intracellular bacteria

Answer 2

Legionella
Chlamydia
Mycobacterium
Listeria

Question 3

Which antibiotics pass into mammalian cells?

Answer 3

Glycopeptides
Macrolides
Quinolones
Tetracyclines

Question 4

Which antibiotic drug accumulates in liver impairment?

Answer 4

Rifampicin

Question 5

Which antibiotic should you NOT drink with?

Answer 5

Metronidazole

Question 6

Which drugs do you not use in renal impairment?

Answer 6

Aminoglycosides

Glycopeptides

Question 7

Which class of antibiotics do you NOT use with statins?

Answer 7

Macrolides

Question 8

What type of medication is a macrolide?

Answer 8

Bacteriostatic
Similar spectrum to Amoxicillin
Active against G -ve and G +ve
Use for PENICILLIN ALLERGIC PATIENTS

Question 9

Which antibiotic would you use for a UTI?
Good oral absorption
Can be used for UTI prophylaxis
Side effects are rare

Answer 9

Trimethoprim

Question 10

What is methotrexate toxicity?

Answer 10

Both trimethoprim and methotrexate reduce folate metabolism, leading to additive effects.

You end up with liver toxicity, bone marrow suppression, neutropenia, and infection.

Question 11

What are the pharmacokinetics of macrolides?

Answer 11

Erythromycin is destroyed by stomach acid (enteric coating)

Iv administration causes phlebitis

Absorption of azithromycin and erythromycin reduced by food.

Inhibits hepatic metabolism of theophyline, warfarin and statins.

Clarythromycin excreted by kidneys (reduce dose in renal impairment)

Question 12

What do you do with Clarithromycin in renal impairment?

Answer 12

Reduce the dose.

Question 13

Which antibiotics do you not use when you’re on Statins?

Answer 13

Macrolides