WBCs Flashcards
Neutrophils aka
Polymorphonuclear Neutrophilic Leukocytes
Segmenters
Most abundant WBC
Neutrophils
Nucleus: NEU
2 to 5 lobes
Neutrophils
Main function is
phagocytosis, leading to the destruction of foreign particles.
First cell to migrate toward the site of infection
Neutrophils
Diapedesis vs Chemotaxis
• Diapedesis: Movement through blood vessel walls to tissues.
Chemotaxis: Migration towards specific areas guided by chemotactic factors.
EOSINOPHILS
• Increase in
allergic reactions or parasitic infections.
• Nucleus: EO
Bilobed or ellipsoidal, often eccentrically located.
EO
Staining:
Takes up acid eosin dye; cytoplasm contains large orange to reddish-orange granules.
BASOPHILS
• Represent less than____ of all circulating WBCs.
1%
BASO nucleus
• Contain coarse, ‘deep-bluish-purple granules that often obscure the nucleus.
• Allergic Reactions:
Regulate T helper cell responses and stimulate B cells to produce |gE.
Basophils
BASO
• ______induces smooth muscle contraction;_____ acts as an anticoagulant.
Histamine
heparin
MONOCYTES
Nucleus:
Irregularly folded or horseshoe-shaped.
MONOCYTES
Cytoplasm:
Ground-glass appearance with fine dust-like granules.
• Precursor for macrophages
Monocytes
MACROPHAGES
Arise from_____.
Differentiation and cell division occur in_____.
monocytes
tissues
Functions:
. Innate Immunity: Microbial killing,
anti-tumor activity, intracellular parasite eradication, phagocytosis, secretion of cell mediators.
Macrophages
• Activation: Enhanced killing activity when activated by microorganisms or cytokines.
Macrophages
Adaptive immunity:
Present antigens to T and B cells.
Macrophages
Macrophages in the blood
Monocytes
Macrophages in the lungs
Alveolar macrophages, dust cells