Complement Chuchu Flashcards
: most abundant complement
C3
; second most abundant complement
C4
: most potent opsonin
C3b
; most potent chemotaxin
C5a
: anaphylatoxins
• C3a, C4a, C5a
• Most common complement deficiency:
C2 deficiency
• Second deficiency that occurs with frequency:
MBL deficiency
• Most severe complement deficiency:
C3 deficiency
MASP-1: Homologous to
C1r
MASP-2: Homologous to
C1s
“MASP:
MBL-associated serine proteases
SLE - like syndrome, recurrent infections
C1
SLE - like syndrome, recurrent infections, atherosclerosis
C2
Severe recurrent infections, glomerulopathies
C3
SLE - like syndrome
CA
Neisseria syndrome
C5- C8
Neisseria syndrome
C5- C8
No known disease association
C9
No known disease association
C9
Hereditary angloedema
C1 INH
No known disease association
C9
Recurrent bacterial infections; glomerulopathies, atypical
Hemolytic Uremic Syndrome
Factor H or Factor I
