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Pathology > WBC Disorders: Pathoma > Flashcards

WBC Disorders: Pathoma Flashcards

1
Q

All WBC’s involve a maturation from what progenitor cell

A

CD34 hematopoietic stem cell

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2
Q

Two stem cells the CD34 hematopoietic stem cell can become?

A
  1. Myeloid stem cell

2. Lymphoid stem cell

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3
Q

Myeloid stem cell will form what four blast cells

A
  1. Erythroblast
  2. Myeloblast
  3. Monoblast
  4. Megakaryoblast
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4
Q

Erythroblast forms what

A

RBC’s

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5
Q

Myeloblast forms what?

A
  1. Neutrophils
  2. Basophils
  3. Eosinophils
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6
Q

Monoblasts form what

A

Monocytes

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7
Q

Megakaryoblasts form what?

A

Megakaryocytes

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8
Q

Lymphoid stem cells will form what two types of blasts?

A

B lymphoblast

T lymphoblast

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9
Q

B and T lymphoblasts will form what?

A

Naive B and T cells

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10
Q

Naive B cells form what?

A

Plasma cells

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11
Q

Naive T cells form what?

A

CD8 and CD4 T cells

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12
Q

Cells mature where?

A

Bone marrow

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13
Q

WBC normal count is what

A

5 to 10 thousand

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14
Q

What is a low WBC count? What is it called?

A

Less than 5

Leukopenia

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15
Q

What is a high WBC count? what is it called?

A

Leukocytosis

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16
Q

A low or high WBC count is usually due to what?

A

Decrease or increase in one particular cell lineage

17
Q

Two types of leukopenia

A

Neutropenia

Lymphopenia

18
Q

Neutropenia causes? (2)

A
  1. Drug toxicity

2. Severe infection

19
Q

Drug toxicity has what effect on neutrophils?

A

Destroys their stem cells

20
Q

Severe infection causes neutropenia why?

A

Neutrophils move into tissues and are no longer counted in blood

21
Q

Treatment for neutropenia?

A

GM-CSF or G-CSF to boost granulocyte production

22
Q

Lymphopenia causes? 4

A
  1. Immunodeficiency
  2. high cortisol state
  3. Autoimmune destruction
  4. Whole body radiation
23
Q

Examples of immunodeficiency causing lymphopenia (2)

A
  1. DiGeorge

2. HIV

24
Q

High cortisol state is caused by what? (2)

A
  1. Cushing syndrome

2. Exogenous corticosteroids

25
Q

Example of autoimmune destruction

A

SLE

26
Q

Whole body radiation is special in regards to lymphopenia why?

A

Lymphopenia is earliest change after whole body radiation

27
Q

5 types of leukocytosis

A
  1. Neutrophilic leukocytosis
  2. Monocytosis
  3. Eosinophilia
  4. Basophilia
  5. Lymphocytic leukocytosis
28
Q

3 causes of neutrophilic leukocytosis

A
  1. Bacterial infection
  2. Tissue necrosis
  3. High cortisol state

Pathology (36 decks)

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