WBC Disorders: Pathoma

Question 1

All WBC’s involve a maturation from what progenitor cell

Answer 1

CD34 hematopoietic stem cell

Question 2

Two stem cells the CD34 hematopoietic stem cell can become?

Answer 2

1. Myeloid stem cell

2. Lymphoid stem cell

Question 3

Myeloid stem cell will form what four blast cells

Answer 3

1. Erythroblast
2. Myeloblast
3. Monoblast
4. Megakaryoblast

Question 4

Erythroblast forms what

Answer 4

RBC’s

Question 5

Myeloblast forms what?

Answer 5

1. Neutrophils
2. Basophils
3. Eosinophils

Question 6

Monoblasts form what

Answer 6

Monocytes

Question 7

Megakaryoblasts form what?

Answer 7

Megakaryocytes

Question 8

Lymphoid stem cells will form what two types of blasts?

Answer 8

B lymphoblast

T lymphoblast

Question 9

B and T lymphoblasts will form what?

Answer 9

Naive B and T cells

Question 10

Naive B cells form what?

Answer 10

Plasma cells

Question 11

Naive T cells form what?

Answer 11

CD8 and CD4 T cells

Question 12

Cells mature where?

Answer 12

Bone marrow

Question 13

WBC normal count is what

Answer 13

5 to 10 thousand

Question 14

What is a low WBC count? What is it called?

Answer 14

Less than 5

Leukopenia

Question 15

What is a high WBC count? what is it called?

Answer 15

Leukocytosis

Question 16

A low or high WBC count is usually due to what?

Answer 16

Decrease or increase in one particular cell lineage

Question 17

Two types of leukopenia

Answer 17

Neutropenia

Lymphopenia

Question 18

Neutropenia causes? (2)

Answer 18

1. Drug toxicity

2. Severe infection

Question 19

Drug toxicity has what effect on neutrophils?

Answer 19

Destroys their stem cells

Question 20

Severe infection causes neutropenia why?

Answer 20

Neutrophils move into tissues and are no longer counted in blood

Question 21

Treatment for neutropenia?

Answer 21

GM-CSF or G-CSF to boost granulocyte production

Question 22

Lymphopenia causes? 4

Answer 22

1. Immunodeficiency
2. high cortisol state
3. Autoimmune destruction
4. Whole body radiation

Question 23

Examples of immunodeficiency causing lymphopenia (2)

Answer 23

1. DiGeorge

2. HIV

Question 24

High cortisol state is caused by what? (2)

Answer 24

1. Cushing syndrome

2. Exogenous corticosteroids

Question 25

Example of autoimmune destruction

Answer 25

SLE

Question 26

Whole body radiation is special in regards to lymphopenia why?

Answer 26

Lymphopenia is earliest change after whole body radiation

Question 27

5 types of leukocytosis

Answer 27

1. Neutrophilic leukocytosis 2. Monocytosis 3. Eosinophilia 4. Basophilia 5. Lymphocytic leukocytosis

Question 28

3 causes of neutrophilic leukocytosis

Answer 28

1. Bacterial infection 2. Tissue necrosis 3. High cortisol state