GI infections Flashcards
Herpes simple is latent where
Trigeminal ganglia
Herpes simple is latent where
Trigeminal ganglia
Herpes simple is latent where
Trigeminal ganglia
Two viral pharyngitis causes
One bacteria
One parasite
EBV
CMV
Group A strep
Toxoplasmosis
Thrush is described how?
Patient type
White plaques on tongue capable of being scraped off
Immunocompromised
Hand-foot-and mouth disease.
Age
Begins how (3)
Form with painful vesicular lesions in throat
Kids
Mild fever + Sores in mouth + Skin rash
Herpangina
H. pylori
Infection leads to what in stomach
Responsible for most of what two things
Two associated cancers
Increased acid production
Chronic gastritis + peptic ulcer disease
Gastric carcinoma and MALT lymphoma
Three most common causes of enterocolitis
What is most common
Rotavirus
Calciviruses
ETEC
Unknown cause most often
Define diarrhea
Increase in mass, frequency or fluidity as perceived by patient.
Define dysentery
Painful bloody diarrhea
3 bacterial mechanisms of infectious diarrhea
Ingestion of preformed toxins
Enterotoxin
Enteroinvasion and cytotoxicity
Lab assessment of secretory diarrhea finds what?
No blood or leukocytes present
Lab assessment of exudative diarrhea finds what?
Blood and/or leukocytes present
Secretory diarrhea is mainly concerned with what mechanism?
Enterotoxin production
Rotavirus What age Cells infected Resulting loss Title Seasonality Primary symptom lasts how long How to test Vaccine
Children Mature enterocytes Loss of absorptive ability Most common cause of diarrhea in kids Winter seasonal pattern 8 days Immunoassay for stool antigen New vaccine just out
Norovirus Responsible for most of what Two symptoms Seasonality DIagnosed how (3) Most common source
Nonspecific diarrhea 12-60 hours of Vomiting and diarrhea Summer diarrhea RIA, PCR, electron microscopy Contaminated water and food at nursing homes and cruise ships
Adenovirus
Age
Diagnosis
4 years old or less
Latex agglutination on stool samples
3 path changes in viral enterocolitis
Shortening of villi
Lymphocytosis of lamina propria
Hyperplasia of crypt cells
Vibrio cholera Severity Primary sign Main mechanism of path How to treat Diagnosis
High mortality in untreated due to fluid loss
Rice water stools
Cholera toxin
Supportive care
Stool culture finds yellow colonies on TCBS medium
ETEC Common cause of Recovery type Two path mechanisms Inflammation involved Diarrhea type
Traveler's diarrhea Self-limited Heat stable toxin and heat labile toxin No inflammation Watery diarrhea
EPEC occurs in what age
Pediatric patients
EHEC Primary strain Associated with what complication in kids Toxin type Effect in blood How to diagnose Two common causes
0157:H7 Hemolytic uremic syndrome in kids Shiga-toxin like Causes platelet aggregation and thrombus Peripheral smear with schistocytes Incompletely cooked meat and petting zoos
EIEC Symptoms identical to what disease Two symptoms Utilize what to enter intestinal cells What toxins
Shigella
Diarrhea and fever
Adhesin proteins allow them to be very invasive
No toxins made
Staph food poisoning Cause of diarrhea Common situation type of toxin recovery length
Preformed toxin
Picnics
Heat stable toxin
2-3 days
Bacillus cereus
Cause of diarrhea
Associated with what
Two toxins, each associated with what
Preformed toxins
Cereals like rice
Emetic toxin: Vomiting within 6 hours
Enterotoxin: Diarrhea disease between 6 and 15 hours after eating
Clostridium perfringens
Cause of diarrhea
Associated with what
Title
Preformed toxin
Poorly cooked pork
Third most common food borne diarrhea cause
Campylobacteri Jejuni Presentation Common with ingesting what (3) Septicemic form Identify how Title
Bloody diarrhea with cramping Poultry + Water + Raw milk Campylobacter fetus Stool culture Most common invasive diarrhea in US
Salmonella typhi Type of diarrhea Primarily occurs when Tissue change seen How to diagnose Common sign of disease
Invasive diarrhea Septicemic form of salmonella Ulcerated peyer's patches Positive blood cultures Rose spots from typhoid fever
Salmonella paratyphoid group Two parts of presentation Species Old diagnosis new diagnosis
Bacteremia + GI presentation
S. enteritidis
O and H typing
Genetic analysis
Shigella Presentation Bacteremic? Flexneri is major cause of what Three signs Associated symptom
Invasive diarrhea No Endemic disease Mucosal ulceration, Rectal bleed + Dehydration Reiter syndrome
C. Diff Two toxins Other name for disease Associated with what use Sign in bowel Title Why New virulent strain Why is it bad
Enterotoxin A and Enterotoxin B Pseudomembranous colitis Antimicrobial use Plaques on bowel Most common infectious diarrhea in hospitals Spores spread B1/NAP1 strain Produces 20X as much A and B toxin
Yersinia enterocolitica Presentation Mimics what two diseases How Most common in what locations Spread how (2)
Invasion with ulceration Mimics Crohn's disease and acute appendicitis Mesenteric granulomatous lymphadenitis Northern lattitudes Milk and meat
Yersinia pseudotuberculosis causes what
Disease similar to Y. enterocolitica
Cryptosporidium parvum Causes what First observed in what Makes this what type of disease Infective dose Places to acquire it (2) Prolonged in who Seasonality
Watery diarrhea Scouring calves Zoonosis As small as one oocyst Swimming pools + Cattle feedlots Immunocompromised Summer
Entamoeba histolytica
Primary histo finding
Liver abscess appears how
Special feature of this disease
Flask shaped ulcers of mucosa
Anchovy paste
Actually digests red blood cells
Giardia
Type of diarrhea
Excreted in poop of what animals (4)
Common place to get it
Malabsorption diarrhea
Bears, cats, dogs, beaver
Daycare centers
Nematode: Ascaris lubricoides
From fecal oral to where
Can cause what in GI
Liver to lungs
intestinal obstruction
Nematode: Strongyloides
Path into body
Go to what organ to induce what
How does it get to GI
Live in ground and penetrate bare feet
Lungs –> Eosinophilic
Larvae are swallowed into GI tract
Nematodes: Hookworms (Necatora/Ancyclostoma)
Enter body how
Get to GI how
Main manifestation
Live in ground and penetrate bare feet
Larvae are swallowed into GI tract
Iron deficiency anemia from blood loss
Nematodes: Enterobius Live where Females do what at night Result Place to get it Diagnostic
Large bowel lumen Females go perianal at night to lay eggs Pruritus ani Day care center Scotch tape test
Cestodes
How to get it
How do they attach to mucosa
Undercooked meat with larvae
Scolex
Cestode diphyllobothrium latum associated with what deficiency
B12
Five F’s of Food borne illness
Feces Flies Fingers Fomites Food
Diarrhea after traveling to boundary waters, Moscow, or Colorado?
Giardia
Diarrhea after going to mexico
ETEC
Diarrhea after going to africa or Haiti?
Vibrio cholera
Diarrhea after antibiotic medications?
C. Difficile
Diarrhea in less than 3 years olds?
Rotavirus
Diarrhea in nursing home
Norrovirus
Diarrhea in toddler at day care center
Giardia
DIarrhea in hospitalized adults
C. diff
Diarrhea from canning
C. botulinum
Diarrhea from milk
Campy
Diarrhea in summer (2)
Cryptosporidium
Norwalk
Diarrhea in winter
Rotavirus
Diarrhea in 1-6 hours
S. aureus
Diarrhea in 1-8 hours
B. cereus
Diarrhea in 1-12 hours
C. perfringens
Diarrhea in 8-48 hours
Salmonella
Diarrhea in 1-3 days
Virus
Diarrhea in 1-7 days
Shigellz
Diarrhea in 5-25 days
Giardia
Mucousy diarrhea cause
Giardia
Two viral pharyngitis causes
One bacteria
One parasite
EBV
CMV
Group A strep
Toxoplasmosis
Thrush is described how?
Patient type
White plaques on tongue capable of being scraped off
Immunocompromised
Hand-foot-and mouth disease.
Age
Begins how (3)
Form with painful vesicular lesions in throat
Kids
Mild fever + Sores in mouth + Skin rash
Herpangina
H. pylori
Infection leads to what in stomach
Responsible for most of what two things
Two associated cancers
Increased acid production
Chronic gastritis + peptic ulcer disease
Gastric carcinoma and MALT lymphoma
Three most common causes of enterocolitis
What is most common
Rotavirus
Calciviruses
ETEC
Unknown cause most often
Define diarrhea
Increase in mass, frequency or fluidity as perceived by patient.
Define dysentery
Painful bloody diarrhea
3 bacterial mechanisms of infectious diarrhea
Ingestion of preformed toxins
Enterotoxin
Enteroinvasion and cytotoxicity
Lab assessment of secretory diarrhea finds what?
No blood or leukocytes present
Lab assessment of exudative diarrhea finds what?
Blood and/or leukocytes present