Pulmonary: Restrictive + Vascular + HTN + Miscellaneous Flashcards
Restrictive lung disease are due to what?
Reduced lung compliance (Hard to fill lungs)
Restrictive
FVC?
FEV1?
FEV1/FVC
FVC: reduced
FEV1: Reduced
FEV1/FVC: Normal
Acute restrictive is defined by what symptoms (4)
- Acute dyspena
- Hypoxia
- Bilateral pulmonary infiltrates
- Absence of left heart failure
How are ALI and ARDS related?
ALI is like early stage ARDS
What are ALI/ARDS the most comon cause of?
Non-cardiogenic pulmonary edema
ALI/ARDS is due to what (2)
- Direct injury to lungs
2. Indirect injury due to systemic disease
Injury to lungs for ALI/ARDS is due to what? (3)
- Infections
- Toxins (Sepsis)
- Trauma
ALI/ARDS path?
- Endothelial injury
- Alveolar edema
- Type II pneumocytes injured
Cause of ALI/ARDS damage?
Imbalance of pro-inflammatory and anti-inflammatory cytokines
3 major morphologic changes in ARDS/ALI?
- Hyaline membrane formation2
- Hepatization of lungs
- Vascular congestion
End stage of ARDS/ALI?
Fibrosis and honey-combing
What do pathologists call ARDS/ALI?
DAD = Diffuse alveolar destruction
When do ARDS/ALI symptoms appear?
Within 72 hours of insult
What % die in ARDS/ALI?
30-40% (pretty high)
How well do ARDS/ALI survivors recover?
Complete regain of function within a year
Chronic restrictive lung disease end-stage? (2)
- Diffuse interstitial fibrosis
2. with or without Honeycombing
What data is important for chronic restrictive diagnosis? (2)
- Social
2. Occupational
Causes of chronic restrictive lung diseases? 7
- Asbestos
- Silicosis
- Coal
- Drugs
- Radiation
- High O2
- Immunologic
Definition of idiopathic pulmonary fibrosis?
Progressive interstitial fibrosis
IPF/UIP sex?
Age?
How is this diagnosed
Males
Elderly
Diagnosis of exclusion
How is the process of IPF/UIP in terms of morphology and age of fibrosis?
Heterogeneous
Main symptom of IPF/UIP?
Slow, continuous dyspnea
Sarcoidosis present how? 5
Lung problem in 90%
Noncaseating granulomas
Bilateral hilar and paratracheal lymphadenopathy (potato nodes)
Interstitial fibrosis
How do you diagnose sarcoidosis?
Diagnosis of exclusion of any other granuloma formers (Myco, Fungi)
Common complications of sarcoidosis besides lung? 2
Eye
Skin
Popuation of Sarcoidosis
Age
Ethnicies
Smoking
Younger than 40
Danes, Swedes, US Blacks »_space;» Whites and Asians
Nonsmokers more common
The presumed cause of sarcoidosis?
Abnormal immune regulation in genetically predisposed people that are exposed to some enviromental stimuli
Genetic factors of sarcoidosis (2)
- Familial and racial clustering
2. Putative antigens like viruses, myco, pollen
Constitutional signs
Fever
Fatigue
Myalgias
What if sarcoidosis has uveoparotid involvement
Mikulicz syndrome
What test is elevated in granulomatous disorders and hence sarcoidosis? 2
ACE elevated (granulomas) Increased urine calcium (granulomas)
Hypersensitivity pneumonitis is defined how?
Immune mediated inflammatory disease of distal lung and alveoli due to sensitivity to inhaled antigens like mold, dust, chemicals