Pathoma: CNS Flashcards
Incomplete closure of neural tube
Neural Tube Defect
Low folate levels prior to conception
Neural Tube Defect
Detected by high AFP levels
Neural Tube Defect
Absence of skull and brain
Anencephaly
Frog-like appearance
Anencephaly
Result in maternal polyhydramnios
Anencephaly
Failure of posterior vertebral arch to close
Spina bifida
Dimple or patch of hair overlying vertebral defect
Spina bifida occulta
Cystic protrusion of underlying tissue through vertebral defect
Spina bifida
Protrusion of meninges
Meningocele
Protrusion of meninges and spinal cord
Meningomyelocele
Congenital narrowing of channel that drains CSF from 3rd to 4th ventricle
Cerebral Aqueduct Stenosis
Most common cause of hydrocephalus in newborns
Cerebral Aqueduct Stenosis
Presents with enlarging head circumference due to dilation of ventricles
Cerebral Aqueduct Stenosis
Congenital failure of cerebellar vermis to develop
Dandy-Walker Malformation
Presents as massively dilated 4th ventricle and absent cerebellum.
Dandy-Walker Malformation
Congenital downward displacement of cerebellar vermis and tonsils through foramen magnum
Arnold-Chiari Malformation Type II
Obstruction results in hydrocephalus
Arnold-Chiari Malformation Type II
May occur in association with meningomyelocele and syringomyelia
Arnold-Chiari Malformation Type II
Cystic degeneration of spinal cord
Syringomyelia
Cause: Trauma or Arnold-Chiari malformation
Syringomyelia
Occurs at C8-T1
Syringomyelia
Presents as sensory loss of pain and temperature with sparing of fine touch and position sense in uppper extremities (Cape-like distribution)
Syringomyelia
Expansion leads to damage of LMN’s of anterior horn (muscle atrophy) and damage of lateral horn of hypothalamospinal tract (Horner syndrome)
Syringomyelia
Damange to anterior motor due to poliovirus infection
Poliomyelitis
Presents with lower motor neuron signs (flaccid paralysis with muscle atrophy, fasciculations, weak muscles, impaired reflexes, and negative Babinski
Poliomyelitis
Inherited Degeneration of Anterior Motor Horn
Werdnig-Hoffman Disease
Autosomal Recessive
Werdnig-Hoffman Disease
Presents as floppy baby, with death within a few years
Werdnig-Hoffman Disease
Degenerative disorder of upper and lower motor neurons of corticospinal tract
ALS
Presents with lower motor neuron signs (flaccid paralysis with muscle atrophy, fasciculations, weak muscles, impaired reflexes, and negative Babinski
ALS
Presents with upper motor neuron signs (spastic paralysis with hyperreflexia, increased tone, positive Babinski sign
ALS
Atrophy and weakness of hands is an early sign
ALS
Lack of sensory impairment distinguishes this from syringomyelia
ALS
Most cases are sporadic arising in middle age adults
ALS
Zinc-copper superoxide dismutase mutation (SOD1) is present in some familial cases, leads to free radical injury
ALS
Degenerative disorder of cerebellum and spinal cord
Friedrich Ataxia
Presents with ataxia (cerebellum) and loss of vibratory sense and proprioception, muscle weakness in legs, and loss of deep tendon reflexes
Friedrich Ataxia
Autosomal recessive due to unstable trinucleotide repeat (GAA) in frataxin gene
Friedrich Ataxia
This mutated protein is essential for mitochondrial iron regulation
Friedrich Ataxia
Presents with iron buildup
Friedrich Ataxia
Presents in early childhood
Friedrich Ataxia
Associated with hypertrophic cardiomyopathy
Friedrich Ataxia
Inflammation of leptomeninges (pia and arachnoid)
Meningitis
Most commonly due to an infectious agent
Meningitis
Most common neonate meningitis causes
GBS, E. Coli, Listeria Monocytogenes
Most common children/teenager meningitis cause
N. Meningitidis
Most common adult and elderly meningitis cause
Streptococcus pneumoniae
Most common non-vaccinated infant meningitis
H. influenza
Most common viral cause of meningitis
Coxsackie virus
Most common immunocompromised cause of meningitis
Fungi
Classic triad of headache, nuchal rigidity, and fever
Meningitis
Diagnosis made by lumbar puncture
Meningitis
CSF finding: Neutrophils with decreased glucose
Bacterial Meningitis
CSF finding: Lymphocytes with normal glucose
Viral Meningitis
CSF finding: Lymphocytes with decreased glucose
Fungal meningitis
Major cause of cerebrovascular disease
Ischemia
Causes: Low perfusion, acute decrease in blood flow, chronic hypoxia, and repeated hypoglycemia
Global Cerebral Ischemia
Presents as transient confusion with prompt recovery
Mild Global Ischemia
Presents as diffuse necrosis with vegetative state
Severe global ischemia
Infarcts in watershed areas (between anterior and middle cerebral rtery
Moderate global ischemia
Damage in this results in laminar necrosis of pyramidal cortex neurons, damage to pyramidal hippocampus neurons, and damage to purkinje layer of cerebellum
Moderate global ischemia
Focal neurologic deficits lasting longer than 24 hours
Ischemic stroke
Focal neurologic deficits lasting less than 24 hours
Transient Ischemic Attack
Due to rupture of an atherosclerotic plaque
Thrombotic stroke
Usually involves the bifurcation of internal carotid and middle cerebral artery in circle of Willis
Thrombotic stroke
Results in pale infarct
Thrombotic stroke
Due to thromboemboli
Embolic stroke
Most common source is left side of heart
Embolic stroke
Usually involves the middle cerebral artery
Embolic stroke
Results in hemorrhagic infarct at periphery of cortex
Embolic stroke
Occurs secondary to hyaline arteriolosclerosis due to hypertension
Lacunar Stroke
Most involve the lenticulostriate vessels resulting in small cystic areas of infarction
Lacunar Stroke
Involvement of internal capsule leads to pure motor stroke
Lacunar Stroke
Involvement of thalamus leads to a pure sensory stroke
Lacunar Stroke
Results in liquefactive necrosis
Ischemic stroke
Presents as eosinophilic/red neurons within 12 hours of occureence
Ischemic stroke
Necrosis occurs by 24 hours
Ischemic stroke
Infiltration of neutrophils in days 1-3
Ischemic stroke
Microglial cells in days 4-7
Ischemic stroke
Gliosis in weeks 2-3
Ischemic stroke
Classically due to Charcot-Bouchard microaneurysms of lenticulostriate vessels
Intracerebral Hemorrhage
Basal ganglia is most common site
Intracerebral Hemorrhage
Presents as severe headache, flu-like, and eventual coma
Intracerebral Hemorrhage
Bleeding into brain parenchyma
Intracerebral Hemorrhage
Bleeding into subarachnoid space
Subarachnoid hemorrhage