Teratogens Flashcards
1
Q
Most commonly used teratogen
A
Ethanol
2
Q
Ethanol side effects? 3
A
- Mental retardation
- ASD
- Head and face abnormalities
3
Q
Thalidomide effects? 2
A
Shortened limbs (phocomelia) (Tha-limb-domide) Represses WNT pathway
4
Q
Phenytoin (Dilantin) effects? 4
A
- Digit hypoplasia
- Cleft lip/palate
- Microcephaly
- Fetal Hydantoin syndrome
5
Q
Methotrexate (folic acid antagonist) 4
A
- Neural tube defects
- Clefts
- GU defect
- CV defect
6
Q
Androgens effect? 3
A
- Low birth weight
- Males have longer fourth fingers
- Females have longer second finger
7
Q
Warfarin/Coumadin effect? 3
A
- Hypoplastic nose
- Stippled epiphyses
- Eye problems
8
Q
Accute/Isotetinoin 3
A
- Face
- CNS
- CV
9
Q
ACE inhibitors
A
Renal defects
10
Q
Cocaine 4
A
- Premature delivery
- Placental abruption
- ADD
- Fetal addiction to cocaine
11
Q
DES 3
A
- Vaginal adenosis
- Vagina clear cell adenocarcinoma
- Mullerian anomalies
12
Q
Iodine absence 2
A
- Congenital goiter
2. Hypothyroidism
13
Q
Maternal diabetes 3
A
- Fetal hyperinsulinemia
- Hypertrophy of pancreatic islets
- Fat