WBC 3 Flashcards
Arises in a single node or chain of nodes and
spreads first to anatomically contiguous
lymphoid tissues
HODGKIN LYMPHOMA
HODGKIN LYMPHOMA
Presence of neoplastic giant cells called
Reed-Sternberg cells
Release factors that induce the accumulation of
reactive
lymphocytes, macrophages, and granulocytes
derived from germinal
center or post—germinal center B cells
Reed-Sternberg cells
More frequent
involvement of multiple
peripheral nodes
Non-Hodgkin
Lymphoma
More often are localized
to a single axial group of
nodes (Cervical ,
Mediastinal, para-aortic)
Hodgkin Lymphoma
Orderly spread by
contiguity
Hodgkin Lymphoma
Mesenteric nodes and
Waldeyer’s ring rarely
involved
Hodgkin Lymphoma
Waldeyer’s ring and
mesenteric nodes
commonly involved
Non-Hodgkin
Lymphoma
Extranodal presentation
rare
Hodgkin Lymphoma
Extranodal presentation is
common.
Non-Hodgkin
Lymphoma
The WHO classification recognizes five subtypes of
Hodgkin lymphoma:
- Nodular sclerosis
- Mixed cellularity
- Lymphocyte-rich
- Lymphocyte depletion
- Nodular lymphocyte predominance
o Large cells with multiple nuclei or a single
nucleus with multiple nuclear lobes, each
with a large inclusion-like nucleolus
about the size of a small lymphocyte (15
to 45 um)
• Diagnostic Reed-Sternberg cells
o Seen in nodular sclerosis subtype
o More delicate, folded, or multilobate nuclei and abundant pale cytoplasm
o Nucleus sitting in an empty space
(lacuna)
• Lacunar cells
o L&H cells o Polypoid nuclei, inconspicuous nucleoli, and moderately abundant cytoplasm o Characteristic of the lymphocyte predominance subtype.
• Lymphohistiocytic variants
