W23-L7: Ageing and Frailty

Question 1

What is Cellular senescence?

Answer 1

where cells lose the

ability to divide

Question 2

What is Organismal senescence?

Answer 2

The ageing of whole organisms

Question 3

T/F Age is not the same throughout the whole body, one organ system could be more aged than another

Answer 3

True

Question 4

What is the physiology behind ageing?

Answer 4

• Inevitable decline due to normal ageing

* Decreased reserve to respond to challenges

Question 5

What is frailty?

Answer 5

Diminished ability to carry out the important practical and social activities of daily living

Question 6

What is frailty associated with?

Answer 6

Low grade chronic inflammation with abnormalities of the endocrine and coagulation system

Question 7

What is sarcopenia?

Answer 7

degenerative loss of skeletal muscle mass

Question 8

What muscles fibres are lost more in ageing and frailty?

Answer 8

Type 2 (fast twitch)&raquo_space; Type 1 fibre

Question 9

What is Fried’s Criteria?

Answer 9

1. Unintentional weight loss
2. Weakness
3. Exhaustion
4. Slow walking speed
5. Low physical activity

Question 10

What is a geriatric syndrome?

Answer 10

The accumulated effect of impairments in multiple domains that together result in a particular adverse outcome