W23-L12: Pathogenesis of Dementia Flashcards
1
Q
What risk factors for AD?
A
Genetics (APP mutations, Apo E) and age
2
Q
What are the four basic types of Alzheimer’s Disease?
A
- Amnestic
- Visuospatial
- Aphasic
- Frontal
3
Q
What is the amyloid cascade hypothesis?
A
Aß aggregation causes amyloid plaque formation and normal clearance cannot remove these plaques
4
Q
What is Aß synaptic toxicity?
A
Synaptic chaos arising from Aß monomers dispersing on membrane surfaces of neurone at extra and intra-synaptic sites
5
Q
What imaging is used for Aß?
A
C-PIB
6
Q
Is both variant CJD blood and sporadic-CJD blood infectious?
A
v-CJD is infectious, sCJD may be infectious
7
Q
What is the estimated incubation period of CJD?
A
At least 6-15 years
