W19-L3: CNS Transmission

Question 1

Central effects of Cocaine

Answer 1

Inhibits Noradrenaline re-uptake

Question 2

Central effects of Amphetamine

Answer 2

Displaces Noradrenaline from storage vesicles (non-exocytotic release)

Question 3

What do dopaminergic neurones in the CNS lack?

Answer 3

Dopamine ß hydroxylase to convert dopamine to noradrenaline

Question 4

T/F A synapse can be both excitatory and inhibitory

Answer 4

False, can be either excitatory OR inhibitory NOT BOTH

Question 5

T/F The same neurotransmitter can be excitatory AND inhibitory

Answer 5

True, Depends on which receptors are present eg Dopamine and Serotonin

Question 6

Ligand gated ion channels in the CNS

Answer 6

Excitatory (Nicotinic)
– Na+ influx driven depolarisation
Inhibitory (GABA A)
– Cl- influx driven hyperpolarisation

Question 7

G protein coupled receptors in the CNS

Answer 7

• activation of second messengers
• modulation of ion channel or enzyme activity
– muscarinic, alpha- and ß-adrenoceptors