Vitamins Flashcards
Vitamin C Another name
(Ascorbic Acid)
Which vitamin’s major functions?
hydroxylating enzymes involved in:
- collagen synthesis
- carnitine synthesis
- tyrosine synthesis and catabolism
- neurotransmitter synthesis
- antioxidant
Vitamin C
Which vitamin’s metabolic pathway? carnitine synthesis in beta oxidation
Vitamin C
Vitamin C Antagonist
heat
light
oxidation
alkaline solutions
large amounts of iron or copper
C Pectin,
zinc,
high intracellular glucose
A single large dose of Ascorbate.
Vitamin C Agonist
Glutathione
Vitamin C RDA/DRI
90mg/d (m)
70mg/d (f)
Which vitamin’s symptoms of deficiency? Scurvy, hyperkeratosis of hair follicles, psychological issues, wound healing, bleeding gums, ruptured capillaries
Vitamin C
Vitamin C Symptoms of toxicity
>2g
gastro problems
Vitamin C Food sources
- fruits and vegetables
- asparagus
- papaya
- citrus
- strawberries
Vitamin C Populations at risk of deficiency
- elderly
- alcoholics
- smokers
Vitamin B1 Another name
Thiamin
Which vitamin’s major functions?
coenzymes(TDP, TPP) involved in:
- energy metabolism (coenzyme role)
- oxidative
- decarboxylation of alpha-keto acids and 2-keto sugars
- DNA, RNA, NADPH + H+ synthesis
- membrane and nerve conduction
Vitamin B1
Which vitamin’s metabolic pathway?
Oxidative decarboxylation of pyruvate,
alpha- ketoglutarate and 3 branched-chain amino acids (pyruvate from glycolysis to Acetyl-CoA),
In TCA cycle
role in the pentose phosphate pathway,
glycolysis
branched amino acid catabolic pathway (into TCA cycle)
Vitamin B1
Vitamin B1 Antagonist
- fish, coffee, tea, berries, brussel sprouts & cabbage can destroy B1
- alcohol can decrease absorption
Vitamin B1 Agonist
-Vitamin C prevents B1 oxidation - Citric Acid
Vitamin B1 RDA/DRI
1.2mg/d (m) 1.1 mg/d (f)
Which vitamin’s symptoms of deficiency? Beriberi, muscle weakness, abnormal gait and mental confusion anorexia tachardia enlarged heart edema Wernicke’s encephalopathy (often with alcoholics) congestive heart failure (wet beriberi) peripheral neuropathy (dry beriberi) Korsakoff syndrome (an often irreversible memory loss and dementia that can follow).
Vitamin B1
Vitamin B1 Symptoms of toxicity
None
Vitamin B1 Food Sources
-pork -whole grains -legumes -tuna -soymilk -yeast -sunflower seeds *Important to not overcook/heat foods with B1
Vitamin B1 Population at risk
-alcoholics -elderly -those with genetic polymorphisms of B1
Vitamin B2 Another name
Riboflavin
Which vitamin’s major function? -coenzymes FAD and FMN -energy metabolism (redox reactions) -metabolism of folate, Vitamin A, niacin, Vitamin B6, and Vitamin K -neurotransmitter metabolism -DNA synthesis
Vitamin B2
Which vitamin’s metabolic pathway? -Electron Transport Chain (hydrogen transfer reactions), -Oxidative decarboxylation of pyruvate, and TCA cycle -fatty acid beta oxidation
Vitamin B2
Vitamin B2 Antagonist
-can be destroyed with exposure to sunlight CU, Zn, Fe, Mn, alcohol
Vitamin B2 Agonist
????
Vitamin B2 RDA/DRI
1.3mg/d (m) 1.1 mg/d (f)
Which vitamin’s deficiency? Ariboflavinosis, cheilosis, glossitis, hyperemia,edema of oral mucous membranes, stomatitis, photophobia, severe deficiency may diminish synthesis of coenzyme form of Vit B6 and synthesis of niacin from tryptophan, DNA damage
Vitamin B2
Vitamin B2 Toxicity
N/A