Viruses Flashcards
List the 5 virus factors
Life cycle
Tropism
Invasiveness
Opportunism
Virulence
What are the host factors?
Age
Genetic
Immune
Trauma
List the sources of viruses
Social
Food
Environment
Occupation
Sexual
Travel
How do we get exposed to viruses?
Orally
Respiratory
Percutaneously
What are the characteristics of viruses that we use to classify them?
Type of nuclei acid: DNA or RNA
Single or double strand
What is the distinguishing feature of a virus?
Obligate intracellular parasites
What proteins to viruses encode for?
Structural and functional proteins for self perpetuation
What cellular components are required for viral propagation?
Translation of viral mRNA
Enzymes for replication
Transport pathways
Energy source
What does the basic virus structure look like?
Envelope
Surface proteins
Capsid
Viral genome
Enzymes
What are the essential components for a virus to have?
DNA/RNA genome
Capsid core
Polymerase protein
What is the protein subunit of a capsid?
Capsomere
What is the viral genome enclosed by?
Nucleocapsid
What are the three types of symmetry in a virus?
Icohedral
Helical
Complex
How does a virus obtains an envelope?
From lipid bilayer of host cell membrane
What does a viral envelope determine?
Stability of virions outside the host
Mode of transmission
What viruses are able to be transmitted by food/water?
Non enveloped - stable
What is the importance of viral surface proteins?
Attach to membrane proteins in host cell
Determine tropism
Target for antibodies
How do viruses replicate?
Attaches to host cell
Passes in through endocytosis
Nucleic acid is uncoated
Viral RNA enters nucleus and is replicated
Release
What is the main concern for the outcome of hepatitis B virus?
Risk of chronic hepatitis
Cirrhosis
Hepatocellular carcinoma
What are four examples of RNA viruses?
Polio
Influenza
Mumps/measles
HIV
How do we diagnose viral infections?
Nucleic acid detection
Antigen detection
What is a superficial viral infection?
Acute infection in epithelium
Short duration 2-4 days
Cold, influenza
What do we call an infection where the virus replicates at multiple sites?
Systemic infection
What is the difference between a persistent and latent infection?
Persistent - continue to produce infectious virus, evade immune system, continue to produce virus
Latent - virally persistent but asymptomatic and do not replicate to produce new viruses