Liver Pathology Flashcards
Where does the liver get its blood supply from?
Portal vein - 70% - from bowel
Hepatic artery - 30% - from stomach/intestine
What are the 7 main functions of the liver?
Protein metabolism - albumin
Carb metabolism - glycogen store
Lipid metabolism - triglycerides store
Bile acid metabolism - production of bile
Protein degradation - ammonia from kidney
Drug and hormone metabolism
Immunological - kupffers cells
What are the main causes of liver disease?
Alcohol
Hepatitis
TB, AIDS
Autoimmunity
Drugs
Iron/copper overload
Obstruction
What are clinical features of liver disease?
Jaundice
Spider veins
Palmar erythema
Clubbing
Bruises
Delayed healing
Confusion
What is hepatitis?
Inflammation of the liver
Causes enlargement, tenderness, deranged function
What is hepatitis caused by?
Viral infection - A B C D E
EBV HIV and rubella too
What is cirrhosis?
Necrosis of liver cells
Fibrosis
Nodule formation
What does cirrhosis cause?
Disruption of blood flow
Loss of liver function
What are the causes of cirrhosis?
Alcohol
Hep B and C
Autoimmune
Wilsons - copper
What is the dental relevance of liver disease?
Drugs can affect liver function
Post op haemorrhage
Cross infection hep B C
Portal hypertension
Avoid IV
How are gall stones formed?
Imbalance of bile pigments, salts and cholesterol
What are complications of gallstones?
Gallbladder - colic, infected cholecystitis
Bile ducts - jaundice, pancreatitis
Gut - gallstone ileus
How much of the cardiac output to kidneys receive?
25%
What are the 4 main functions of the kidney?
Excretion of waste
Homeostasis
Blood pressure
Hormone synthesis
What are the main causes of renal failure and damage?
Diabetes
Hypertension
What is the dental relevance of renal disease?
Renal failure
Dialysis
Transplant
What are the clinical features of renal problems?
Painful pee
Haematuria
Urinary retention
Urine volume