Gastro Pathology Flashcards
What are the 3 ways gastrointestinal disorders can be divided into?
Inflammatory - peptic ulcer disease, coeliac, Crohns, ulcerative colitis
Neoplastic - carcinoma of the oesophagus, stomach, colon
Functional - achalasia, diverticulosis, IBS
What three things do oesophageal disorders present with?
Dysphasia - difficulty swallowing
Pain - acid reflux, spasm, similar to cardiac pain
Cough/vomit - reflux
What is a pharyngeal pouch?
Herniation of mucosa
Weakness in pharyngeal constrictor muscles
Behind sternocleidomastoid
How does a pharyngeal pouch present?
Hangs due to gravity
Dysphagia
Swelling in lower neck on left side
Regurgitation
Overflow into lungs - respiratiory
What are the 2 causes of dysphagia?
Obstructive - tumours, inflammation, fibrosis, drugs, surgery, narrowing
Neuromuscular - stroke, Parkinson’s, MS, spasm, achalasia
What is achalasia?
Loss of ganglia from intramural plexus
LOS does no relax
Oesophagi does not empty
Failure of peristalsis and dilation of oesophagus
Regurgitation
What is the treatment for achalasia?
Nifedipine to relax sphincter
Balloon dilation
Cardiomyotomy
What are some causes of an oesophageal spasm?
Achalasia
Reflux
Motor disorders
Obstruction
Neuromuscular
How does oesophageal web occur?
Mucosa turns to atrophic, fibrous stricture
Upper end of oesophagus
Web on barium swallow
Pre-malignant
Iron deficiency anaemia
What is the treatment for oesophageal web?
Dilatation of stricture
Correction of iron deficiency
What are the causes of carcinoma of oesophagus?
Smoking
Alcohol
Pharyngeal pouch
Peptic ulcer disease
Achalasia
Coeliac
Iron deficiency - oesophageal web
What is the pathology of oesophageal carcinomas?
Squamous cell carcinoma
Spread to lymph nodes
Metastasises to liver
What are the clinical features of carcinomas of the oesophagus?
Dysphagia
Pain on swallowing
Local spread pain
What is the treatment of oesophageal carcinomas?
Surgery for cure
Radiotherapy - not adenocarcinoma
Stenting
What is the dental relevance of oesophagus carcinoma?
Dysphagia could be malignancy
Medicines in liquid form
What areas do peptic ulcers affect?
Oesophagus
Stomach
Duodenum
What is the cause of peptic ulcer disease?
Mucosal inflammation - H. Pylori infection
Oesophagus ulceration - acid reflux
Stomach ulceration - NSAIDs
Duodenal ulceration - gastric acid production
What is the pathology of peptic ulcer disease?
Ulcers lead to healing with scarring - strictures
Chronic ulcers
Acute perforation
What are the clinical features of peptic ulcer disease?
Pain relieved by eating
Stricture - vomiting
Perforation - vomit blood
What is the treatment of peptic ulcer disease?
Antacids
H2 blockers
Proton pump ihibitors
Eradicate H. Pylori infection