Virology8 Flashcards
EBV Genome length: Host cell: Causes--------- Receptor: Genome type: Reactivation will lead to:
1-172 kb 100 genes (70 proteins)
2-B lymphocytes (can transmitt it to other by circulation) in salivary glands
3-Acute infectious mononucleosis (increasing monocytes, glandular fever)
4-C3b (complement receptor)
DNA
Lysis of cell
T or F
EBV is not oncogenic
False
Types of antigens presented by EBV
Latent phase:
1-EBNA1 maintain episomes in circular shape in nucleas
2-LMP1:activated GF receptor
Early antigens: NSPs onset of replication (functional antigens)
Late: VIral capsid-envelope antigens
Interpret: VCA IgM + VCA IgG + EBNA IgG- -------- VCA IgM - VCA IgG + EBNA IgG + ------- VCA IgM + VCA IgG + EBNA IgG + ------ Oral viral load remain more than blood-----
Acute infection
Past infection
Reactivation
Capable of more shedding
Persistence of the virus is caused by ——–
In germinal B cells because of latency this leads to ——
Change in latent antigens
Hodgkin lymphoma and burkitts
Two oncogenic forms of EBV infection after latency are:
Hodgkin’s lymphoma
Burkitt’s lymphoma
Associated with nasopharyngeal carcinoma
EBV causes polyclonal stimulation of ——-
Mononucleosis:
B cells
Mononucleosis is the polyclonal stimulation
Monospot test(sheep blood) is used to detect presence of —— which indicates if it’s positive the presence of —— mainly or ——
Heterophil antibody
EBV ( 80% of cases)
CMV (20% of cases)
Infectious mononucleosis
IP: Symptoms: Severity: Residual symptoms: Transmission: High risk Adult seroconversion:
Ip: 1-2 months Symptoms: fever- sore throat(white patches) and tonsils may block airways- LN-splenomegaly(rapture)-hepatomegaly(hepatitis and elevated LFT) Self-limited but doesn't disappear quickly. Not children (bekun milder la age of 5) Bkhaf mn strepA Chronic Fatigue syndrome and myalgia Through saliva and contact (kissing) 90% by age of 40-50
If an EBV infected patient was given penicillin this will lead to———, this will (remain/disappear) —— after stopping this med
Pruritic maculopapular rash
Disappear
How can we detect EBV by CBC?
Thrombocytopenia
Neutropenia
T or F
T lymphocytes are not affected by EBV
False
They have atypical shape
Burkitt’s lymphoma is caused by EBV and —— which is a co-factor, this will lead to ——- and over expression of —— this oncogene will lead to burkitts lympho
Malaria
Chromosome translocation
C-myc
The most painful cancer caused by EBV is ——-
Jaw sarcoma
T or F
White people are more likely to produce infectious mono
True
T or F
Black people are more likely to make tumors
True because of latency
Nasooharyngeal carcinoma is more common in ——- it affects —- and —–
Southern eastern asian males (chinese)
Pharynx
Eustachian tube
T or F
EBV causes nasooharyngeal carcinoma
False
It’s associated with it
I can find by pcr EBV DNA
Oral hairy leukoplakia is caused by —– mainly in ——-,immunosuppressed patients may suffer from —— characterized by hepatic necrosis and ——
EBV
Immunosuppressed patients (AIDS)
Lymphoproliferative disease
Pancytopenia
T or F
CMV can infect every organ
True
Breast milk
Shedd in stool
Mode of transmition of CMV
Breast milk
Sexual contact
Fecal oral
Site of latency:
Kidney
Spleen, wen ma ken
Myeloid cells of bone marrow
After —— we should do the CMV antibodies test
Transplantation ( eg. Kidney)
Shape of CMV on microscope:
Owl eye
T or F
CMV is a slow replicator
True
Unlike Like HSV which is fast
CMV in immunosuppresed patients can cause:
Colitis
Pneumonitis
Chorioretinitis (T4 less than 10)
Hepatitis
T or F
EBV can’t cause hepatitis
False
Congenital CMV:
Petechiae(non blanching)-jaundice-hepatosplenomegaly
Hearing loss
Chorioretinitis
Strabismus (حول( whde mn l occular muscles mesh shaghale)
Organisms Causing microcephaly:
Toxoplasma Others (syphilis and zeka) Rubella CMV HSV
Why do they call infetious mono glandular fever?
Because it causes the enlagement of the RE system (liver-spleen-LN)
Africans tumors are 90% positive for ——
EBV
cmv symptoms during pregnancy
Vasculitis (uterus or placenta ) that lead to hypoperfusion
Microcephaly
Polyhydramnios (excess amniotic fluid)
Olygoamnios ( less amniotic fluid)
T or F
Jaundice is common in adult EBV infection than congenital one caused by CMV
False
Reversed
Pregnant woman should’t come in contact with —— and ——- because CMv could be transmitted by saliva
Toddlers
Young babies
Echolalia habet
T or F
CMV is a co-factor for HIV infection
True Increased T4 proliferation Direct transactivator of latent HIV Inhibit apoptosis of HIV infected cells Inflammation and altered trafficking Induction of inhibitory pathways
HHV 6 and 7 cause rash called------aka---starts with ------ last to ------ and the infant is (active/no)---- Also may cause : Self limited or chronic: Latency: Associated with :
Exanthem subitum aka Rosiola infantum High fever (40 ) 3-5 days (looks active) Uvulopalatal (papules)(2/3 of patients) Then macculopapular rash after the fever is gone (trunk then neck face and extremity) (rash from 1 to 2 days) Malaise Irritability Conjunctivitis Anorexia Self limited Have latency Multiple sclerosis and alzeheimers or encephalitis (neurotropic)
Kaposi sarcoma
Caused by HHV8
People livin with AIDS
Appear anywhere on skin
Violet to black lesions
