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Virology > Virology8 > Flashcards

Virology8 Flashcards

1
Q 
EBV
Genome length:
Host cell:
Causes---------
Receptor:
Genome type:
Reactivation will lead to:
A

1-172 kb 100 genes (70 proteins)
2-B lymphocytes (can transmitt it to other by circulation) in salivary glands
3-Acute infectious mononucleosis (increasing monocytes, glandular fever)
4-C3b (complement receptor)
DNA
Lysis of cell

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2
Q

T or F

EBV is not oncogenic

A

False

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3
Q

Types of antigens presented by EBV

A

Latent phase:
1-EBNA1 maintain episomes in circular shape in nucleas
2-LMP1:activated GF receptor

Early antigens: NSPs onset of replication (functional antigens)

Late: VIral capsid-envelope antigens

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4
Q 
Interpret:
VCA IgM +  VCA IgG +  EBNA IgG- --------
VCA IgM - VCA IgG + EBNA IgG + -------
VCA IgM + VCA IgG + EBNA IgG + ------
Oral viral load remain more than blood-----
A

Acute infection
Past infection
Reactivation
Capable of more shedding

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5
Q

Persistence of the virus is caused by ——–

In germinal B cells because of latency this leads to ——

A

Change in latent antigens

Hodgkin lymphoma and burkitts

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6
Q

Two oncogenic forms of EBV infection after latency are:

A

Hodgkin’s lymphoma
Burkitt’s lymphoma
Associated with nasopharyngeal carcinoma

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7
Q

EBV causes polyclonal stimulation of ——-

Mononucleosis:

A

B cells

Mononucleosis is the polyclonal stimulation

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8
Q

Monospot test(sheep blood) is used to detect presence of —— which indicates if it’s positive the presence of —— mainly or ——

A

Heterophil antibody
EBV ( 80% of cases)
CMV (20% of cases)

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9
Q

Infectious mononucleosis

IP:
Symptoms:
Severity:
Residual symptoms: 
Transmission:
High risk
Adult seroconversion:
A 
Ip: 1-2 months
Symptoms: fever- sore throat(white patches) and tonsils may block airways- LN-splenomegaly(rapture)-hepatomegaly(hepatitis and elevated LFT) 
Self-limited but doesn't disappear quickly.
Not children (bekun milder la age of 5)
Bkhaf mn strepA
Chronic Fatigue syndrome and myalgia
Through saliva and contact (kissing)
90% by age of 40-50
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10
Q

If an EBV infected patient was given penicillin this will lead to———, this will (remain/disappear) —— after stopping this med

A

Pruritic maculopapular rash

Disappear

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11
Q

How can we detect EBV by CBC?

A

Thrombocytopenia

Neutropenia

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12
Q

T or F

T lymphocytes are not affected by EBV

A

False

They have atypical shape

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13
Q

Burkitt’s lymphoma is caused by EBV and —— which is a co-factor, this will lead to ——- and over expression of —— this oncogene will lead to burkitts lympho

A

Malaria
Chromosome translocation
C-myc

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14
Q

The most painful cancer caused by EBV is ——-

A

Jaw sarcoma

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15
Q

T or F

White people are more likely to produce infectious mono

A

True

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16
Q

T or F

Black people are more likely to make tumors

A

True because of latency

17
Q

Nasooharyngeal carcinoma is more common in ——- it affects —- and —–

A

Southern eastern asian males (chinese)
Pharynx
Eustachian tube

18
Q

T or F

EBV causes nasooharyngeal carcinoma

A

False
It’s associated with it
I can find by pcr EBV DNA

19
Q

Oral hairy leukoplakia is caused by —– mainly in ——-,immunosuppressed patients may suffer from —— characterized by hepatic necrosis and ——

A

EBV
Immunosuppressed patients (AIDS)
Lymphoproliferative disease
Pancytopenia

20
Q

T or F

CMV can infect every organ

A

True
Breast milk
Shedd in stool

21
Q

Mode of transmition of CMV

A

Breast milk
Sexual contact
Fecal oral

22
Q

Site of latency:

A

Kidney
Spleen, wen ma ken
Myeloid cells of bone marrow

23
Q

After —— we should do the CMV antibodies test

A

Transplantation ( eg. Kidney)

24
Q

Shape of CMV on microscope:

A

Owl eye

25
Q

T or F

CMV is a slow replicator

A

True

Unlike Like HSV which is fast

26
Q

CMV in immunosuppresed patients can cause:

A

Colitis
Pneumonitis
Chorioretinitis (T4 less than 10)
Hepatitis

27
Q

T or F

EBV can’t cause hepatitis

A

False

28
Q

Congenital CMV:

A

Petechiae(non blanching)-jaundice-hepatosplenomegaly
Hearing loss
Chorioretinitis
Strabismus (حول( whde mn l occular muscles mesh shaghale)

29
Q

Organisms Causing microcephaly:

A 
Toxoplasma
Others (syphilis and zeka)
Rubella 
CMV
HSV
30
Q

Why do they call infetious mono glandular fever?

A

Because it causes the enlagement of the RE system (liver-spleen-LN)

31
Q

Africans tumors are 90% positive for ——

A

EBV

32
Q

cmv symptoms during pregnancy

A

Vasculitis (uterus or placenta ) that lead to hypoperfusion
Microcephaly
Polyhydramnios (excess amniotic fluid)
Olygoamnios ( less amniotic fluid)

33
Q

T or F

Jaundice is common in adult EBV infection than congenital one caused by CMV

A

False

Reversed

34
Q

Pregnant woman should’t come in contact with —— and ——- because CMv could be transmitted by saliva

A

Toddlers

Young babies

35
Q

Echolalia habet

A
36
Q

T or F

CMV is a co-factor for HIV infection

A 
True
Increased T4 proliferation
Direct transactivator of latent HIV
Inhibit apoptosis of HIV infected cells
Inflammation and altered trafficking
Induction of inhibitory pathways
37
Q 
HHV 6 and 7 cause rash called------aka---starts with ------ last to ------ and the infant is (active/no)---- 
Also may cause :
Self limited or chronic:
Latency:
Associated with :
A 
Exanthem subitum aka Rosiola infantum 
High fever (40 )
3-5 days (looks active)
Uvulopalatal (papules)(2/3 of patients)
Then macculopapular rash after the fever is gone (trunk then neck face and extremity) (rash from 1 to 2 days)
Malaise
Irritability
Conjunctivitis
Anorexia
Self limited
Have latency
Multiple sclerosis and alzeheimers or encephalitis (neurotropic)
38
Q

Kaposi sarcoma

A

Caused by HHV8
People livin with AIDS
Appear anywhere on skin
Violet to black lesions

Virology (12 decks)

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