Virology6 Flashcards
Rhabdoviruses :
Shape:
Envelope:
Genome :
Helical
Present
RNA negative stranded
T or F
Rabies virus have a dead end host
No human to human trans
True
T or F
Rabies virus targets the digestive system
False
CNS
Development of symptoms of rabies:
- unresponsive then tremors and visual hallucinations
- calm , alert and lucid with headache and discomfort + dysphagia
- delirious state and violence
- coma and death (day 4)
Who invented the vaccine against rabies?
Louis pasteur
Genus:Lyssavirus Shape of envelope: Genome: Name of glycoprotein present: Development of disease: Genome type and size
Bullet shaped or rod shaped SsRNA negative stranded G glycoprotein (spike) Acute-fulminant(exagerated)- fatal Single stranded - RNA 12 kb
T or F
Cats and dogs are the most susceptible for rabies
False
Less likely ymut mena
T or F
Bats can’t transmit rabies to humans
False
They can
Receptor for rabies:
Viral attachment protein for rabies:
Replication:
Nicotinic Ach receptor on muscles
G spike
-ve btser positive btaamele proteins w btrjaa btser negative to make the genome (by rna dependent rna polymerases L and P)
T or F
N protein is found in the envelope of rabies virus
False
Capsid
Site of multiplication of rabies: Projection of the virus on various organs: 1- 2- 3- 4- 5- 6-
Muscle/connective tissue multiplication
1- muscle (multiplication for weeks or months between myocytes and nerve ending)
2-neurons (soma)
3- dorsal ganglion of spinal cord/spinal cord
4-salivary gland (submaxillary)
5-skin
6- eye (cornea)
——- are pathognomonic for rabie and they stain ——- in soma although —– of infected people don’t have it
Negri bodies
Eosinophilic
20%
T or F
Rabies causes viremia
False
IP for rabies virus is variable because the more —— the bite is the longer the IP will be
In face:
Distal
1 week
Rabies in acute neurologic phase differs from —— to ——- , we have —— overreactivity with—–,—— and —– occurs also the patient starts—–behaviour with —-
——- is phathognomonic to rabies
Paralytic rabies dies (faster/slower)——Furious rabies leads to —–
Encephalitis to paralytic Sympathetic system Salivation Hydrophobia Aerophobia Hydrophobia (spasm of esophagus) (pathognomonic) Photophobia Bizzare Delirium Faster because of paralysis of diaphragm Coma/salivation and dilation
MR for rabies is—–
IP for rabies:
> 99%
1-3 months
T or F
Regarding the manner of attack, we give the vaccine to people bitten by provoked dogs
False
Name of vaccine for rabies
Verorab
T or F
Treatment of rabies doesn’t include giving antibodies
False
We giveIgGs
Antibodies adminstered (40mg/kg) will be given half in ——- and another one —–
Wound area
Intamusculatr (gluteal area) ( on the opposite side of the vaccine krmel ma yaamlu agglutination)
T or F
After abrasion we should give the IgGs with the vaccine
False
Only the vaccine
Touching and licking on intact skin we should recommend——
Nothing
Nibblig or licking of uncovered skin with bleeding we should recommend—–
The vaccine and IgGs
The vaccine and IgGs when adminstered together they should be given—–
On opposite sides
Prions Devoid of----- Misfolded proteins named----- IP: Inflammatory response: Influence by immunosuppression:
Nucleic acid/not living just a protein Misfolded PrP Months to years No inflammatory response No influence on IS
Prions form —– accumulation in CNS tissue like —— and —-
Amyloids
Alzeheimer and parkinson
T or F
TSE can be caused by de novo mutations
False
Caused by eating infected cows
Rotavirus Genome: Capsid shape: Envelope: Disease; Mode of transmission:
Double stranded RNA 11 segments Icosahedral (double concentric capsid shells) Bo envelope Diarrheal disease in infants GI (fecal oral)
Group— is the main serotype causing disease from the serotypes —- to —
A
A to H
—- of children infected with rotavirus will end up being hospitalized
50%
The most affected age —- to —–
6m to 2 y
Rabies can be transmitted from ——-
Dogs
Racoons
Rats
—— is usually felt around the bite of the dog
Numbness and tingling
Phases of rabies
1- prodrome:
Fever
Pruritus
Paresthesia
Vaccine for dogs is —- doses
2
T or F
Rats in lebanon cause rabies
False
Only in one case baate l vaccine
Mtl l case l bent le ken l jardun aam yekela b eda
In addition to rabies vaccine we should also give —– and check for his vaccination file to know if we should give——
Antibiotics (risk of infection)
Tetagam or tetavax
T or F
If a dog bites a man in his penis we should give the IgG in the site of bite
False
This will cause necrosis of the penis
I give it in the inguinal area
