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Virology > Virology6 > Flashcards

Virology6 Flashcards

1
Q

Rhabdoviruses :
Shape:
Envelope:
Genome :

A

Helical
Present
RNA negative stranded

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2
Q

T or F
Rabies virus have a dead end host
No human to human trans

A

True

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3
Q

T or F

Rabies virus targets the digestive system

A

False

CNS

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4
Q

Development of symptoms of rabies:

A
  • unresponsive then tremors and visual hallucinations
  • calm , alert and lucid with headache and discomfort + dysphagia
  • delirious state and violence
  • coma and death (day 4)
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5
Q

Who invented the vaccine against rabies?

A

Louis pasteur

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6
Q 
Genus:Lyssavirus
Shape of envelope:
Genome:
Name of glycoprotein present:
Development of disease:
Genome type and size
A 
Bullet shaped or rod shaped
SsRNA negative stranded
G glycoprotein (spike)
Acute-fulminant(exagerated)- fatal
Single stranded - RNA 12 kb
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7
Q

T or F

Cats and dogs are the most susceptible for rabies

A

False

Less likely ymut mena

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8
Q

T or F

Bats can’t transmit rabies to humans

A

False

They can

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9
Q

Receptor for rabies:
Viral attachment protein for rabies:
Replication:

A

Nicotinic Ach receptor on muscles
G spike
-ve btser positive btaamele proteins w btrjaa btser negative to make the genome (by rna dependent rna polymerases L and P)

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10
Q

T or F

N protein is found in the envelope of rabies virus

A

False

Capsid

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11
Q 
Site of multiplication of rabies:
Projection of the virus on various organs:
1-
2-
3-
4-
5-
6-
A

Muscle/connective tissue multiplication
1- muscle (multiplication for weeks or months between myocytes and nerve ending)
2-neurons (soma)
3- dorsal ganglion of spinal cord/spinal cord
4-salivary gland (submaxillary)
5-skin
6- eye (cornea)

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12
Q

——- are pathognomonic for rabie and they stain ——- in soma although —– of infected people don’t have it

A

Negri bodies
Eosinophilic
20%

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13
Q

T or F

Rabies causes viremia

A

False

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14
Q

IP for rabies virus is variable because the more —— the bite is the longer the IP will be
In face:

A

Distal

1 week

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15
Q

Rabies in acute neurologic phase differs from —— to ——- , we have —— overreactivity with—–,—— and —– occurs also the patient starts—–behaviour with —-
——- is phathognomonic to rabies
Paralytic rabies dies (faster/slower)——Furious rabies leads to —–

A 
Encephalitis to paralytic
Sympathetic system 
Salivation
Hydrophobia
Aerophobia
Hydrophobia (spasm of esophagus) (pathognomonic)
Photophobia
Bizzare
Delirium
Faster because of paralysis of diaphragm
Coma/salivation and dilation
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16
Q

MR for rabies is—–

IP for rabies:

A

> 99%

1-3 months

17
Q

T or F

Regarding the manner of attack, we give the vaccine to people bitten by provoked dogs

A

False

18
Q

Name of vaccine for rabies

A

Verorab

19
Q

T or F

Treatment of rabies doesn’t include giving antibodies

A

False

We giveIgGs

20
Q

Antibodies adminstered (40mg/kg) will be given half in ——- and another one —–

A

Wound area

Intamusculatr (gluteal area) ( on the opposite side of the vaccine krmel ma yaamlu agglutination)

21
Q

T or F

After abrasion we should give the IgGs with the vaccine

A

False

Only the vaccine

22
Q

Touching and licking on intact skin we should recommend——

A

Nothing

23
Q

Nibblig or licking of uncovered skin with bleeding we should recommend—–

A

The vaccine and IgGs

24
Q

The vaccine and IgGs when adminstered together they should be given—–

A

On opposite sides

25
Q 
Prions
Devoid of-----
Misfolded proteins named-----
IP:
Inflammatory response:
Influence by immunosuppression:
A 
Nucleic acid/not living just a protein
Misfolded PrP
Months to years
No inflammatory response
No influence on IS
26
Q

Prions form —– accumulation in CNS tissue like —— and —-

A

Amyloids

Alzeheimer and parkinson

27
Q

T or F

TSE can be caused by de novo mutations

A

False

Caused by eating infected cows

28
Q 
Rotavirus
Genome:
Capsid shape:
Envelope:
Disease;
Mode of transmission:
A 
Double stranded RNA 11 segments
Icosahedral (double concentric capsid shells)
Bo envelope
Diarrheal disease in infants
GI (fecal oral)
29
Q

Group— is the main serotype causing disease from the serotypes —- to —

A

A

A to H

30
Q

—- of children infected with rotavirus will end up being hospitalized

A

50%

31
Q

The most affected age —- to —–

A

6m to 2 y

32
Q

Rabies can be transmitted from ——-

A

Dogs
Racoons
Rats

33
Q

—— is usually felt around the bite of the dog

A

Numbness and tingling

34
Q

Phases of rabies

1- prodrome:

A

Fever
Pruritus
Paresthesia

35
Q

Vaccine for dogs is —- doses

A

2

36
Q

T or F

Rats in lebanon cause rabies

A

False
Only in one case baate l vaccine
Mtl l case l bent le ken l jardun aam yekela b eda

37
Q

In addition to rabies vaccine we should also give —– and check for his vaccination file to know if we should give——

A

Antibiotics (risk of infection)

Tetagam or tetavax

38
Q

T or F

If a dog bites a man in his penis we should give the IgG in the site of bite

A

False
This will cause necrosis of the penis
I give it in the inguinal area

Virology (12 decks)

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