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Virology > Virology3 > Flashcards

Virology3 Flashcards

1
Q

Paramyxovirus

Genome:
Envelope:
Shape:
Trans:

A

Ss RNA negative sense
Enveloped
Helical NC
RT

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2
Q

Mumps and measles ard transmitted —– although they cause —— aka —–

A

RT
Dissemenated disease
Systemic viruses

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3
Q

T or F

H and N proteins in paramyxo are of great importance

A

False

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4
Q

T or F

Paramyxo have matrix

A

True (M protein)

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5
Q

Fate of -ve strand RNA on paramyxo viruses

A

-make the +ve strand
1- will make mRNA that will make proteins of the virus
2-remain as template to make the viral -ve RNA

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6
Q

T or F

Nipah virus is paramyxovirus

A

True

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7
Q

T or F

Parainfluenza can’t infect adults

A

False it can

But most diseases are in children

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8
Q 
If an immunocompetent person infected with parainfluenza this will lead to ----- disease like ----- (can/can't)----- cause viremia, can dissemenate to the larynx causing :
1-
2-
3-
4-
A 
Mild - like common cold
Can't cause viremia
1-Laryngotracheobronchitis = croup
2-pneumonia 
3-bronchiolitis
4- otitis media
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9
Q

Stridor:

A

الشهقة

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10
Q

Standard care for croup patients

A

Supportive care
Corticosteroids
Oxygen therapy
Epinephrine by nebulizer to open the vocal cords

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11
Q

RSV is the most common cause of ——– in infants and young children

A

Lower respiratory tract

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12
Q

RSV replicates in —– and spread too —— and may cause —– (more/less) ——common than parainfluenza in severity

A

Nasopharynx
Respiratory tract (bronchiolitis and pneumonia)
More

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13
Q

Serious period is between —- of age where after the latter he has no risk of detrimental disease

A

6 weeks and 6 months

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14
Q

T or F

We should give the neonates a medication without knowing the cause when fever occurs because it’s very dangerous

A

False
We should know if it’s UTI RT or CNS
Because fever in such young age is alarming

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15
Q

Adults usually get better after —– of infection with RSV while children takes ——-

A

2 days

2 weeks

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16
Q
  • —– infected by RSV by age 1

- —– by age 2

A

70-%

100%

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17
Q

T or F

RSV is cytopathic

A

Yes because it form syncytia (giant cell)

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18
Q

F spike protein is a —– protein found in —— virus

A

Fusion

RSV

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19
Q

T or F

RSV is not bimodal

A

False it is

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20
Q

T or F

RSV is not very common in a nosocomial setting

A

False

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21
Q

Tx for RSV

A

Ribavirin (children mainly)

22
Q

Mode of trans of RSV

A

Large droplets

Contact

23
Q

Is there a vaccine for RSV?

A

Nah

If there is it should be for the mother so that she can give her child passive immunity

24
Q

Mumps (can/can’t) —– cause systemic diseases eventually lead too ——-&——, —— of the infections are asymptomatic

A

Can
Meningitis(more common in males) and orchitis
35%

25
Q

T or F

The child infected with mumps can transmitt the virus even before the prodromal phase

A

True

26
Q

T or F

Humans ain’t the only reservoir for mumps

A

False

27
Q

Parotitis a characteristic of —— and it’s (obligatory/non)—— step of this virus, the virus (can/can’t)—– cause viremia

A

Mumps virus
Non obligatory
Can

28
Q

Mumps is viscerotropic and can cause ——- and—— then we can detect it in ——- aka —–
IP:

A 
Pancreatitis
Kidneys
Urine after 2 weeks of symptoms
Viuria (can detect it after 2 weeks of symptoms)
2 to 4 weeks
29
Q

Mumps is more common in (males/females)——- which causes —– more than ——

A

Males
Orchitis
Oophoritis

30
Q

——— virus is very very very infectious unlike mumps and varicella

A

Measles

31
Q

After meningitis mumps can cause —– and ——- which may be self limited
Immunity:

A

Meningoencephalitis
Unilateral deafness
Permanent

32
Q

MR of mumps is ——

A

1%

33
Q

Swelling of testicles caused by mumps is (common/uncommon)—— because of tunica albuginea unlike in ovaries but in both we have risk of —–

A

Uncommon

Infertility

34
Q

T or F

Mumps can be transmitted through kissing

A

True

35
Q

Measles is always ——, causes ——-illness with —–, — host , —- serotype(s)
Like mumps —– is not effective because it’s symptomatic before apearance of the —– protection with mmr to measles is —- while for rubella—-

A 
Symptomatic
Febrile respiratory illness
Macculopapular rash
1 host and 1 serotype
Quaratine
Rash
>99%
92-95
36
Q

After secondary viremia rubeola virus this virus attacks 3 sites
1-
2-
3-

A

Skin: macculopapular face then trunk then limbs, coalescence with no scarring
RT: cough , rhinitis
Conjunctiva

37
Q

In immunocompromised kids 1 in 1000 will develop——

A

Encephalitis

38
Q

Rash appear after —– the invasion of the virus while prdromal illness with the cough,—– and rhinitis appear after ——

A

2 weeks
Koplik spots
1 week

39
Q

In koplik spots we (can/can’t) —— detect the measles virus and —— cells

A

Can (have viral antigens)

Multinucleated giant cells

40
Q

Koplik spots are (pathognomonic/not) —— for measles

A

Pathognomonic

41
Q

Koplik spots colour:

A

Blueish to whitish

42
Q

Giant cell pneumonia is present in ——patient

A

HIV

43
Q

Modified measles

A

Measles infection to a patient with maternal immunity or taken 1 dose
No koplik spots

44
Q

T or F

Measles can cause otitis externa

A

False

Otitis media

45
Q

PIE:
MIBE:
SSPE:

A

PIE: 7 to 28 days autoimmune targeting myelin and causing encephalitis then sequela
MIBE: inclusions in nerves because of immune problems (defective immune sys)
SSPE: from 5 to 15 years after infection because of multiplication in CNS without budding ( no M protein) this will lead to mental deterioration, involuntary movements , rigidity and coma
This will happen for all patients infected with measles
3 years and the patient will die

46
Q

Can we differentiate between macculopapular rash between measles and rubella clinically?
Risk of mutation for measles?

A

No
The only difference is that rubella rash disappears after 3 day

None

47
Q 
MMR(V)
Form:
Doses:
Risk of encephalitis for vaccinated:
Risk of rash:
A 
Live attenuated
1st dose 12-15 months (after maturation of thymus)
2nd dose 1.5 years till 3
Before school 
1 in 1 million
Present like in all vaccines
48
Q

T or F

In Bacterial fever the patient usually looks more ill than viral one

A

Yes because it’s usually more septic

49
Q

Otitis media is a very common feature of —— virus

A

Measles

50
Q

Symptoms of measles:

A

Coryza (rhinitis)- cough-conjunctivitis
Lymphopenia
Koplik spots

Virology (12 decks)

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