Virology3 Flashcards
Paramyxovirus
Genome:
Envelope:
Shape:
Trans:
Ss RNA negative sense
Enveloped
Helical NC
RT
Mumps and measles ard transmitted —– although they cause —— aka —–
RT
Dissemenated disease
Systemic viruses
T or F
H and N proteins in paramyxo are of great importance
False
T or F
Paramyxo have matrix
True (M protein)
Fate of -ve strand RNA on paramyxo viruses
-make the +ve strand
1- will make mRNA that will make proteins of the virus
2-remain as template to make the viral -ve RNA
T or F
Nipah virus is paramyxovirus
True
T or F
Parainfluenza can’t infect adults
False it can
But most diseases are in children
If an immunocompetent person infected with parainfluenza this will lead to ----- disease like ----- (can/can't)----- cause viremia, can dissemenate to the larynx causing : 1- 2- 3- 4-
Mild - like common cold Can't cause viremia 1-Laryngotracheobronchitis = croup 2-pneumonia 3-bronchiolitis 4- otitis media
Stridor:
الشهقة
Standard care for croup patients
Supportive care
Corticosteroids
Oxygen therapy
Epinephrine by nebulizer to open the vocal cords
RSV is the most common cause of ——– in infants and young children
Lower respiratory tract
RSV replicates in —– and spread too —— and may cause —– (more/less) ——common than parainfluenza in severity
Nasopharynx
Respiratory tract (bronchiolitis and pneumonia)
More
Serious period is between —- of age where after the latter he has no risk of detrimental disease
6 weeks and 6 months
T or F
We should give the neonates a medication without knowing the cause when fever occurs because it’s very dangerous
False
We should know if it’s UTI RT or CNS
Because fever in such young age is alarming
Adults usually get better after —– of infection with RSV while children takes ——-
2 days
2 weeks
- —– infected by RSV by age 1
- —– by age 2
70-%
100%
T or F
RSV is cytopathic
Yes because it form syncytia (giant cell)
F spike protein is a —– protein found in —— virus
Fusion
RSV
T or F
RSV is not bimodal
False it is
T or F
RSV is not very common in a nosocomial setting
False
Tx for RSV
Ribavirin (children mainly)
Mode of trans of RSV
Large droplets
Contact
Is there a vaccine for RSV?
Nah
If there is it should be for the mother so that she can give her child passive immunity
Mumps (can/can’t) —– cause systemic diseases eventually lead too ——-&——, —— of the infections are asymptomatic
Can
Meningitis(more common in males) and orchitis
35%
T or F
The child infected with mumps can transmitt the virus even before the prodromal phase
True
T or F
Humans ain’t the only reservoir for mumps
False
Parotitis a characteristic of —— and it’s (obligatory/non)—— step of this virus, the virus (can/can’t)—– cause viremia
Mumps virus
Non obligatory
Can
Mumps is viscerotropic and can cause ——- and—— then we can detect it in ——- aka —–
IP:
Pancreatitis Kidneys Urine after 2 weeks of symptoms Viuria (can detect it after 2 weeks of symptoms) 2 to 4 weeks
Mumps is more common in (males/females)——- which causes —– more than ——
Males
Orchitis
Oophoritis
——— virus is very very very infectious unlike mumps and varicella
Measles
After meningitis mumps can cause —– and ——- which may be self limited
Immunity:
Meningoencephalitis
Unilateral deafness
Permanent
MR of mumps is ——
1%
Swelling of testicles caused by mumps is (common/uncommon)—— because of tunica albuginea unlike in ovaries but in both we have risk of —–
Uncommon
Infertility
T or F
Mumps can be transmitted through kissing
True
Measles is always ——, causes ——-illness with —–, — host , —- serotype(s)
Like mumps —– is not effective because it’s symptomatic before apearance of the —– protection with mmr to measles is —- while for rubella—-
Symptomatic Febrile respiratory illness Macculopapular rash 1 host and 1 serotype Quaratine Rash >99% 92-95
After secondary viremia rubeola virus this virus attacks 3 sites
1-
2-
3-
Skin: macculopapular face then trunk then limbs, coalescence with no scarring
RT: cough , rhinitis
Conjunctiva
In immunocompromised kids 1 in 1000 will develop——
Encephalitis
Rash appear after —– the invasion of the virus while prdromal illness with the cough,—– and rhinitis appear after ——
2 weeks
Koplik spots
1 week
In koplik spots we (can/can’t) —— detect the measles virus and —— cells
Can (have viral antigens)
Multinucleated giant cells
Koplik spots are (pathognomonic/not) —— for measles
Pathognomonic
Koplik spots colour:
Blueish to whitish
Giant cell pneumonia is present in ——patient
HIV
Modified measles
Measles infection to a patient with maternal immunity or taken 1 dose
No koplik spots
T or F
Measles can cause otitis externa
False
Otitis media
PIE:
MIBE:
SSPE:
PIE: 7 to 28 days autoimmune targeting myelin and causing encephalitis then sequela
MIBE: inclusions in nerves because of immune problems (defective immune sys)
SSPE: from 5 to 15 years after infection because of multiplication in CNS without budding ( no M protein) this will lead to mental deterioration, involuntary movements , rigidity and coma
This will happen for all patients infected with measles
3 years and the patient will die
Can we differentiate between macculopapular rash between measles and rubella clinically?
Risk of mutation for measles?
No
The only difference is that rubella rash disappears after 3 day
None
MMR(V) Form: Doses: Risk of encephalitis for vaccinated: Risk of rash:
Live attenuated 1st dose 12-15 months (after maturation of thymus) 2nd dose 1.5 years till 3 Before school 1 in 1 million Present like in all vaccines
T or F
In Bacterial fever the patient usually looks more ill than viral one
Yes because it’s usually more septic
Otitis media is a very common feature of —— virus
Measles
Symptoms of measles:
Coryza (rhinitis)- cough-conjunctivitis
Lymphopenia
Koplik spots
