Virology2 Flashcards
Picornaviruses are (small/big)-----less than ------ (single/double)----- (RNA/Dna)-------(icosahedral/helical)-----(enveloped/not)------ They are divided into ------- transmitted thru----- and -------- transmitted thru----
Small 50 nm Single RNa pos Icosahedral Naked Enteroviruses GIT Rhino RT
T or F
Hepatitis B is a picornavirus
False
Hepatitis A
Poliovirus is (naked/enveloped)------ virus----- (enterovirus/rhino)------causes the destrusction of ----- so called ----- Transmitted thru ----- route
Naked
Entero
Myelin shealth ,poliomyelitis
Fecal oral route
Pathogenesis of polio:
Ingestion Local LN Primary viremia Secondary viremia Muscle then CNS (retrograde)
How many type of polio viruse we have?
Type of vaccine?
3 with cross reactivity
Trivalent vaccine
T or F
After recorvery and carriers can transmitt the virus to others (prolonged excretion of virus)
True
T or F
Humans are not the only reservoir for poliovirus
True
We have the primates too
95% of polio patients are ——- while 5%——, IP ——
Asymptomatic (subclinical)
Clinical
IP 1 to 2 weeks
In the clinical case of polio , there is a spectrum of this clinical disease
Talk about it
Mild , only with prodromal illness
Non paralytic , aseptic meningitis ( self limited unlike bacterial meningitis) last for 1 weeek
Paralytic poliomyelitis atrophy of proximal muscles , hip dysplagia and scoliosis
Post poliomyelitis infection
Residual paralysis
Progressive post poliomyelitis muscle atrophy
T or F
Poliovirus can’t affect adults
False
But it’s mainly in children
Endemic vs epidemic
Endemic is continous camp of refugees where there is no sudden rise in infected people because of lack of sanitation
Epidemic there is sanitation but there is a sudden rise in infected people before vaccination era
Vaccines of polio
Salk: inactive-virus can’t multiply given PRT no herd immunity virus still (keep shedding virus because of ansence of IgA) transmitted (we have IgM and igG)
Sabin : live attenuated given PO induce igA and trivalent (1,2,3), herd immunity
Coxsackivirus is (enterovirus/rhinovirus)——–divided into —- and —– causes —–foot mouth disease (involve/not ) —— palm and soles, causes —– rash (with/without) ——- crusting unlike —– and —– ,mainly in —— and (require/doesn’t) ——- treatment
Entero A and B Hand foot mouth disease Involve Vesicular Without crusting Herpes and small pox Children Doesn't
T or F
Only type A can cause aseptic meningitis
False
Both
Enteroviruses are the most common cause of ——- in adults
Viral meningitis
2 diseases associated with coxsackie B
Pleurodynia aka epidemic myalgia : fever then ,abdominal(in children) pleuritic and chest pain.
Myocarditis coxsackie is the number 1 cause of myocarditis in all viruses that causes it
Acute (heart failure) or chronic (chronic heart failure.
T or F
Only coxsackie B can cause common cold and gastroenteritis
False both
——— can cause undifferentiated febrile illness
Coxsackie
T or F
Coxsackie can cause inteference with affects vaccination
True
Generalized disease of infants
The invasion of virus in all tissues this will lead to excessive secretion on interferons and cytokines and the baby will die eventually