Virology12 Flashcards

1
Q

T or F

Immunosuppresion caused by HIv has the same influence as that of organ transplant

A

False

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2
Q

Primary acute HIV syndrome is much like that of—— so we call it —–
Some of it’s symptoms are :
1-
2-

A

EBV
Mononucleosis like syndrome
Hepatosplenomegaly
Pruritic Rash

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3
Q

T orF

Signs of HIV acute syndrome are clear ,specific and we can tell that this patient has HIv from this stage

A

False

Most patiets enter the clinical latency without anyone knowing

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4
Q

T or F

In HIv we have viral latency

A

False

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5
Q

T or F
If the patient came with recurrent diarrhea and night sweats, candidisis
This raise the suspicion that he might have HIV

A

Truee

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6
Q

T or F

In acute HIV syndrome we have immunosuppresion

A

False

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7
Q

T or F

HIV acute syndrom can’t go asymptomatic

A

False

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8
Q

People who have covid and living with HIV but on HAART have (severe/normal)—– infection. They might have (longer/shorter)—— covid symptoms.
The most cases of HIV are in —— where we have ——— and——,that was the problem regarding ppl livin with HIV.

A
Normal
Longer
Africa
Low vaccination
Overwhelming of healthcare sys
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9
Q

People living with HIV are like COVID patients are prone to —– and —– on the long term

A

Cardiovascular disease

Diabetes

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10
Q

T or F

During clinical latency the patient is not infectious

A

Akid infetious le3en den l manta2a

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11
Q

Oral hairy leukoplakia as a —— is caused by —– in immunosuppresed patients or even in ——-

A

Constitutional symptom
EBV
Early acute HIV syndrome

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12
Q

——- is caused by HHV8 in immunosupp ppl, which is ——

A

Kaposi sarcoma

Connective tissue malignant cancer

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13
Q

T or F

Kaposi sarcoma is a blanching macculopapular rash

A

False

Non blanching

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14
Q

T or F

Most of kaposi sarcomas are unnoticed

A

True (taht usbaa ejru)
We should always examine skin and oral cavity
Pleaseeeeee shufun

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15
Q

Data showed we have (male/female) —— predisposition to kaposiii

A

Male

Male:female (17:1)

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16
Q
AIDS defining illness
1-
2-
3-
4-

+1-
2-
3-

A

1-CD4<200
2-pulmonary tuberculosis
3- recurrent pneumonia
4-invasive cervical cancer

Kaposi
Pneumocystis carini pneumonia (b america is more prevalent than TB so by3tbruwa as aids defining illness)
Esophageal candidasis

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17
Q

TB infection increases by —– fold in HIV patients, we can screen by—- and —–

A

20 fold
PPD (>5)
Chest x ray looking for tubercles and not granulomas (laanu l granuloma kter zghar) (tubercles hene majmu3t granulomas)

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18
Q

Coccidioides immitis aka —— caused by —— , causes —– fever but in immunosupp ppl it will cause —– or —— when the CD4 drops below—–
Mainly in ——(country)

A
Coccidioidomycosis
Mycelium of fungu
Valley
Very severe pneumonia
Meningitis
250
USA
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19
Q

Pneumocystis carini pneumoniae aka —–is a —– causes —–,—– and ——
However in immunosuppressed patients it causes ——- that appear on CT scan like —–, when the CD4 drops to ——
Prophylaxis:

A
Jirovecii
Yeast fungus
Fever-dyspnea-cough
Ground glass pattern pneumonia
CoViD
Less than 200
Bactrim
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20
Q

T or F

Fungal pneumonia or recurrent bacterial pneumoni in a healthy looking patient is suspicious and i should do HIv test

A

True

21
Q

T or F

Recurrent Bacterial pneumonia appears only when CD4 count drops below 200

A

False

May appear on 400-500

22
Q

Main bacteria that causes recurrent pneumonia :
1-
2-

A

Hemophilus influenzae

Strep pneumonia

23
Q

Candida albicans causes —— in immunocompetent patients while in immunosuppressed ppl it causes mainly —— and ——, when the CD4 count drops below—–

A
Superficial friable white lesions on mucosa only (mesh mtl l oral leukoplakia ma beruhu)
Esophageal candida (can be from 
omeprazole)
And cutaneous candida
200
24
Q

Histoplasma capsulatum are —— fungus live in —– and it can be —–, feathers of the bird and GI of —-, in immunosuppresed patients it causes—– which can be confusing with —– also can cause ——- when the CD4 count drops below—–

A
Dimorphic
Soil
Airborne
Bats
Granulomatous pulmonary disease
TB
Dissemenated histoplasmosis rash
150
25
Q

Cryptococcus neoformans is aquired from ——, in immunosuppressed it causes —– when the CD4 count drops below —–

A

Pidgeon droplets
CNS disease (encephalitis or meningitis)
100

26
Q

Cryptosporidium parvum and —– causes —— in HIV patients when the CD4 count drops below —–

A

Isospora belli
Chronic diarrhea (feha tkun mn giardia aw salmonellaa)
100

27
Q

The diarrhea is considered persistent after —– and chronic after ——

A

2 -4 weeks

1 month

28
Q

HSV causes ——- in HIv patients but will be ——- that will be (painless/painful)——also on the anal level it will develop to——
Also may cause—– and ——
When the CD4 count drops below—–

A
ulcers
Severe and chronic
Very painfulll
HSV proctitis
Esophagitis
Eczema herpeticum
100
29
Q

Ulcers are considered chronic after ——

A

Few weeks (1-2 months)

30
Q

JC virus in normal individual causes —– while in HIV patients it causes ——-
Progressive because it appears as —–,—– and —— those will lead to —– when the CD4 count drops below—–
Tx:—–

A
Asymptomatic to prodromal
Prog multifocal leukoencephalopathy
Vision problems , speech and personality shifts
Prog weakness
100
HAART
31
Q

JC virus is transmitted thru—– with latency in —– and —–, reactivation happens when we have ——
Transported thru the BBB inside—-

A

Inhalation
Kidney and bone marrow
Immunosuppresion
B cells

32
Q
CMV causes  ------- under --- CD4 count and can cause -----, on the brain level it causes ----
And ------ in GIT
When the CD4 count drops below----
Tx:
Also we should ----
A
Retinitis 
1
Blindness
Encephalitis
Colitis
50
Acyclovir(?) with HAART
Screen
33
Q

If we wanna diagnose the disease with CMV we should ask for —— or —–, if below 50 and i wanna know if he has CMV i make ——

A

PCR from stool specimen or CSF

Serology

34
Q

T or F

Every organ can be involved in CMv

A

True

35
Q

CMV is a —– for HIV

A

Co-infection

36
Q

Mycobacterium avium complex below cd4—- causes —— and —-

A

50
Anemia
Dissemination RES

37
Q

T or F

Mycobacterium avium is atypical and causes the disease alone

A

False

Multiple microorganisms

38
Q

Toxoplasma gondi causes —— under cd4 count of ——

We should screen at —-

A

Space occupying lesions/neuroligical manefistations
50
Any CD4 count like in TB

39
Q

T or F

Mycobacterium avium is the the most common cause of neurological manefistation with a patient livin with AIDS.

A

False

Toxoplasmosis

40
Q

HPV is the —– STI in most people it’s —– and——-
Genome:
Envelope:
Cutaneous HPV is (malignant/not)—– but in cervix or —–it’s —– and it causes —–

A
Most common in the whole world
Dormant
Oncogenic
DsDNA circular
Naked
Not
Penis
Malignant
Dysplasia
41
Q

Screening for HPV:
Vaccines for HPV:
Vaccines is recommended for ——

A

Pap smear
Gardasil
Cervarix
Women and men

42
Q

List some microorganisms when present we will be more exposed to HIV because of broken skin: (co-infections) or co-factors

A
Hemophilus ducreyi
Treponema pallidum
HCV
EBV
CMV
HSV
HBV
43
Q
Pediatric AIDS 
Clinical latency : 
Death (without HAARt):
Oral candidiasis is (less/more) ------ severe than adults, with ------ and ------
------ because of bacteria with ------
A
2
4
More
Encephalopathy-pneumonitis(inflamation of conn tissue)/ pneumonia
Sepsis
Wasting
44
Q

Aids causes ——- aka—– and —–on CNS on the long run by destruction of —–, also—— on PNS

A

Dementia aka aids dementia complex
Aseptic meningitis
Neurons
Peripheral neurophathy (bebatl yhes b ejre)

45
Q
AIDS dementia complex characterisation:
1-
2-
3-
4-
5-
A
Memory loss
Concentration
Apathy
Psychomoto problem
Behaviour (awkward)
46
Q

Without HAART, after aids dementia complex the patient will die in —–
Neurological consequences of HIV along with cancer caused by HIv will (complete/stop)—— with treatment

A

6 m

Complete regardless of treatment

47
Q
Ppl livin with HIV and taking HAARt have higher risk of :
1-
2-
3-
4-
A
Cardiovascular disease
Dementia
Diabetes 
Cancer (CNS lymphoma and burkitts)
2C 2D
48
Q
HAART:
Current problem is because of:
U=U:
Effect of uncompliance in therapy:
3 fam of drugs:
Reason of triple therapy:
Prep:
Role of prep:
Composition of prep:
Paradoxycal effect of prep:
A

Highly active antiretroviral therapy
Stigma
Untrasmissible if undetected viral load even if it’s unprotected sex
Resistance
2 nucleoside reverse transcriptase inhibitors + 1 nonnucleoside or integrase inhibitor
If one have resistance there are other 2 working
Pre-exposure prophylaxis: HIV will not transmitted by having sex with a HIV+
Prep=treatment -1
less condoms usage fa balash ynta2al eshya tenye (ducreyi,syphilis)

49
Q

T or F

Universally the highest HIV percentage is amongst homosexuals

A

False

Laanu b africa (2/3 of cases) are among heterosexuals