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Virology > Virology7 > Flashcards

Virology7 Flashcards

1
Q 
Herpesviridae 
genome:
Spectrum of infections:
Host range:
Type of infection:
Reactivation:
High risk patients:
Shape of capsid:
Envelope
Presence on site of lesion
A 
DNA (linear ds)
Wide
From narrow(EBV) to wide
Persistent latent infection (viral latency)
Periodic
Elderly and immunosuppressed
Icosahedral
Present
Not present lama ykun saheh
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2
Q

T or F

Herpes viruses don’t have tegument

A

False

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3
Q

T or F

HSV 1 and 2 have 70% homology

A

False

50%

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4
Q

Terminal and internal repeats are involved in ——-

A

Gene rearrangement

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5
Q

T or F

In general herpes viruses resemble each other

A

False

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6
Q

We know which virus it is from —— which is adding endonucleases and then ——-

A

Finger printing

Migrating fragments on southern

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7
Q

In the latent phase the DNA takes a —— shape

A

Circular

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8
Q

Replication of herpes viruses:

A

Adsorption (the virus sticks to GAGs like heparan sulfate)
The capsid enters the cell
The DNA is thrown thru the nuclear pore (uncoating)
The DNA becomes circular
Bser mtl l episome
Tegument protein initiates the replication:
Immediate early : alpha proteins
Early: beta
Late: gamma (structural)
Cellular RNA pol II
MicRNA regulates the expression (latency)

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9
Q

HSV1 and 2 can cause :

1-
2-
3-
4-

A

Skin infections (burning,tingling—) macules then small bumps then vesicles then ulcer (vesiculo ulcerative lesions)
Mucosal
Encephalitis
Conjunctivitis

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10
Q

Herpes viruses hide in ——— in HSv1 and in —— in HSV2
They are homologous by —–

A

Dorsal ganglia of trigeminal nerve
Dorsal ganglie of sacral plexus
50% (fhemna)

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11
Q

HSV I is mainly transmitted thru—-
HSV 2 transmitted thru——
The reverse is (possible/not)—

A

Saliva (orall) (1 tongue)
Genitally (2 genitals)
Possible

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12
Q

T or F

We should screen for HSV 2/1

A

False

And antibody is useless laanu 3/4 l aalam already exposed

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13
Q

T or F

Antibody test should be done for detection of HSV 1

A

False
80-90% has been exposed to HSV1
Common epitopes between 1 and 2

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14
Q

T or F

Herpes viruses are cytolytic

A

True

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15
Q

T or F

We can differentiate clinically between HSV and varicella

A

False both cause painfull vesiculo ulcerative lesions

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16
Q

Site of primary infections should be either —– or —— , (can/can’t)—– transmitt the virus if he is asymptomatic.

A

Mucosal surfaces or breached skin

Can

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17
Q

Primary infection is (more/less) ——- severe than reinfection amd that’s because of ——-

A

More

Immune system

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18
Q

Cowdry type A are (intracutoplasmic/intranuclear)——- bodies present after infection with ——– while type B are present in——

A

Intranuclear
Varicella zoster
HSV

CMV

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19
Q 
Primary infection(rarely/often)-----can cause meningitis and encephalitis, by which it's (mild/severe)----- and can leave ------- resulting in -----
Primary infection in an intact skin (will/less likely happen)------ the most common case is transmission by----
A 
Rarely
Mild
Sequela
Hear loss
Less likely
Mucosal
Breached skin
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20
Q

Immunocompromised patients infected with HSV can suffer from ——- after——

A

Ulcers and vesicles on the esophagus

Viremia

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21
Q

Reactivation can be caused by :

A

Uv rays
Stress
Menstruation

22
Q

The most seen for of herpes is —— presented by small vesicles on lips (with/without) —— crusting

A

Cold sore

With

23
Q

IP for HSV

A

Few days to 3 weeks

24
Q

Symptoms of HSV1 mainly

A 
Fever sore throat (prodrome)
Vesicular ulcerative lesions 
Gingivitis mainly in children
Adults : pharyngitis and tonsilitis
Keratoconjuctivitis : will heal unless we have ulcers on the cornea(corneal ulcers) and lens that will lead to blindness
25
Q

Strep A can be accompanied with ——-,—— and —— viruses

A

EBV
CMV
HSV

26
Q 
Genital herpes
Mainly caused by ------
Painful for-----
Site of infection:
Spread to---
Could cause---
A 
HSV 2
3 weeks
Genitals or perineum and thighs
LNs enlargement
Aseptic meningitis in primary infection
27
Q

T or F

Herpes can cause secondary bacterial infections because of ulcers

A

True

28
Q

T or F

Herpes can’t cause pus

A

False

29
Q

Herpetic whitlow is most common in —— upon small cuts or contamination on hands or toes

A

Hospital staff

Surgeries

30
Q

Herpes gladiatorum seen in ———

A

Athletics

31
Q

Eczema herpeticum signs:

A 
Malaise
Skin lesions
Itchy painful blisters and ulcers
Enlaged lymph nodes
Red purple and black blisters
Dermatits is very common in children ( elbows and knees) and popliteal
L jeled neshef (xerosis)
And rhinitis then this kid has eczema
We should always put hydrating creams
32
Q

Neonatal herpes

-/—- delivers
Mode of trans:
Symptoms:
In neonates most common cause of death is because of —-

A

1/5000
During delivery
Localized/encephalitis or disseminated
Viral pneumonitis

33
Q

Tx for HsV

A

Acyclovir (nucleoside analog)
Important in neonates
Eza baad 72 hrs ma baate she laanu mtl eltu (this applies to all anti-viral drugs)

34
Q

The only virus that causes all forms of rash at the same time is —– also characterized by——

A

Varicella zoster virus (chicken pox)

When prodrome disappears rash appears even if vaccinated

35
Q

T or F

Macules appear in case of VZV infection (brown patches)

A

False

This case was for fungal infection

36
Q

——- is very ——– but not as measles

But varicella in children is —— unlike —–

A

VZV
Contagious
Mild
Measles

37
Q

Zoster is the —— of ——

A

Reactivation

Varicella

38
Q

Zoster can be diagnosed clinically by appearance of ——- rash

A

Dermatomal

Pic of the trigeminal (ophthalmic)

39
Q

Postherpetic neuralgia is ——pain from —— not from —-, it happens after——
Treated by —— or —- which are —-
The virus send messages of pain from —-

A 
Neuropathic
CNS not periphery
Infection (not infected anymore)
Pregabalin or gabapentin
Antiepileptic drugs
CNS
40
Q

T or F

Zoster can’t be bilateral

A

False in immunosuppresed it could be bilateral

41
Q

Immunity against VZV is —— however it’s just against—– not to —–

A

Permanent lifelong
Varicella (chicken pox)
Zoster

42
Q

CMV duration of replication:

HSV duration of rep and clinical manifestation:

A

Slow

Quick

43
Q

T or F

50% of herpes genes are not active in vitro

A

True

Because they need the host gene apparatus this allows us to make antiviral drugs (acyclovir)

44
Q

T or F

In HSV asymptomatic patients don’t transmit the virus

A

False

Because most of primary infections are asymptomatic

45
Q

T or F

Secondary herpes infection is more severe

A

False

Milder

46
Q

In varicella the rash begins on —- then —– then ——

A

Face
Trunk
Extremities

47
Q

Macules:
Papule:
Vesicle:

A

Red spots or brown
Bumps
Fehn may

48
Q

In varicella we check —– it will appear as ——- that resemble the —-

A

Oral mucosa
1 little vesicle on soft palate
Koplik spot of measles

49
Q 
VZV can cause 
1-
2-
3---- except in ------
We usually are scared from varicella pneumonia in:
1-
2-
A

Encephalitis
Sequela
Varicella pneumonia except in healthy children

Pregos
People with malignancies (hodgkin,leukemias, lymphoproliferative diseases like EBV)

50
Q

Tzanck smear is caused by ——

A

VZV

51
Q

The most complication of zoster after the neurologic disorders is ——-

A

Superinfections

Virology (12 decks)

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