Viral Infection Process

Question 1

Steps of viral infection

Answer 1

Attachment, entry, uncoating, synthesis of protein and nucleic acid, assembly and release

Question 2

Attachment and entry of naked

Answer 2

Spikes bind to receptor…receptor mediated endocytosis (in a vesicle)…release into cytoplasm and then uncoated

Question 3

Attachment and entry of enveloped

Answer 3

Envelope will fuse to cell membrane…nucleocapsid will enter the cell and then uncoated

Question 4

After replication, what happens to each

Answer 4

Naked exit via cytolysis
Enveloped RNA “Bud” from the host cell using cell membrane
DNA will exit in vesicle via exocytosis using nuclear membrane as new envelope

Question 5

Naked viruses type of infection

Answer 5

Not persistent because must kill cell to infect another cell

Question 6

Possible effects of viral infection on host cell

Answer 6

Abortive where no progeny produced
Productive viral infection where host not killed and virus released
Latent infection where incorporated into DNA or stays as episome…reactivated later
Viral infection results in death and production of progeny

Question 7

Patterns of viral infection and examples

Answer 7

Acute infection followed by clearing - Hep A
Acute infection followed by latent infection and periodic reactivation - HSV 1,2
Acute infection followed by chornic infection - Hep C
Acute infection followed by persistent infection and virus overproduction - HIV