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Foundations 7 > Immunity to Eukaryotic Pathogens > Flashcards

Immunity to Eukaryotic Pathogens Flashcards

1
Q

PMNs important for

A

Asperigillus
Mucor
Candida

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2
Q

Macrophage important for

A

Pneumocystis, cryptococcus, blastomyces, histoplasma, aspergillus

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3
Q

Opsonic phagocytosis

A

Use complement or AB

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4
Q

Non-opsonic phago

A 
B glucan receptors (dectin 1, pneumo, candidia, asperigllus, coccidiodes)
Mannose receptor (Candida, coccidiodes, pneumo) and TLRs (TLR2,4 and cryptococus)
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5
Q

CD4s

A

Provide help to phagos and B cells..produce IFNgamma and TNFalpha

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6
Q

Th1 immunity

A

Histoplasma, cryptococcus, blastomyces, aspergillus

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7
Q

CD8

A

Histoplasma and blastomyces

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8
Q

Granuloma formation

A

Important with histoplasma and many fungi will produce DTH response

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9
Q

HUmoral immunity

A

Cryptococcus and pnuemo

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10
Q

Macrophages will produce

A

IL-10, 12, and 18 that help mature dendritic cell

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11
Q

Th1 produces

A

IFNgamma and TNFalpha to help activate macros

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12
Q

Th2 produce

A

IL4 and 5 impotant for B cell

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13
Q

Th17 produces

A

IL-17 important for neutrophil activation

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14
Q

Plasmodium dzs and principal immune mechs

A

Malaria

ABs and CD8s

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15
Q

Leishmania dzs and mechs

A

Leischmaniasis

CD4 Th1 cells help activate macros

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16
Q

Trypanosoma dz and mech

A

Trypanosomiasis

ABs

17
Q

Entamoeba histolytica dz and mech

A

Amebiasis

ABs and phago

18
Q

Schistosoma dz and mech

A

Schistosomiasis

Esosinophils and macros

19
Q

Filaria dz and mech

A

Filariasis

CMI and ABs?

20
Q

Eosinophil act mech

A

Th2 produces IL-5 which activates Fc epsilon rceptor of the mast cell

21
Q

Th2 production against helminths

A

IL-13 increases production of epithelial cells…more mucous
IL-5 recruits eosinophils
IL-4 drives B cells to produce IgE
IL-3 and IL-9 recruit mast cells to tissue (cause muscle spasms, diarrhea that expel)

22
Q

Th1 production against helminths

A

IFNgamma activates macrophages and disrupts infected tissues
Also helps produce IgG which has not effect against helminths

23
Q

Malaria innate response in liver

A

Produce type 1 IFNs and IFN gamma

24
Q

Malaria adaptive liver response

A

Depends on CD8 cells

25
Q

Malaria blood stage immunity

A

Th1 cells protect with IL-10 and IFNgamma activation…Th2 cells induce AB response

26
Q

Toxoplasma gondii gut mucosal response

A

Gets through gut and activates Th1 cells to produce IFNgamma to activate monos and macros to kill parasite

27
Q

IFNgamma sources for toxoplasm defense

A

CD4
NK cell (activated by IL-12 from dendritic)
Neutrophil
CD8 (activated by infected dendritic)

All prime the macro to kill by NO toxicity and decreased tryptophan

Foundations 7 (19 decks)

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