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Foundations 7 > Mechanisms of Immunization > Flashcards

Mechanisms of Immunization Flashcards

1
Q

DTaP

A

Toxoid, protein subunit
Diptheria toxin, tetanus toxoids, pertussis hemagglutinin and outermembrane proteins
Aluminum adjuvant and formaldehyde

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2
Q

Tdap

A

Toxoid, protein subunit
Diphtheria toxin (reduced), tetanus toxoids, pertussus hemagglutiinin and outer membrane proteins
Aluminum adjunvent and formaldehyde

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3
Q

Hib

A

For haemo influenz
Polysaccharide protein conjugate
Conjugates of tetanus toxoid OR N meningitidis outer membrane protein plus capsule type B

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4
Q

MPSV4 vaccine

A

Neisseria Meningitidis
Polysaccharide subunit
INactivated subunit vaccine of polysaccharide types A, C, Y, W135
Thimerosal

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5
Q

MCV 4

A

N meningi
Polysacch protein conjugate
Conjufate of diptheria toxin and polysaccharide types A, C, Y, W135
Formaldehyde

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6
Q

Men B

A

N mening
Recombinant subunit
Genes for adhesion A, factor H binding, and/or heparin binding proteins
Aluminum

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7
Q

PPSV23

A

Strep Pneumo
Polysaccharide subunit
Inactive subunit vaccine of polysaccharide

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8
Q

PCV13

A

Strep pneuo
Polysaccharide protein conjugate
Conjugate of tetanus toxoid and polysaccharide
Aluminum

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9
Q

HAV

A

Hep A
Inactivated
Whole virus
Aluminum, formaldehyde, neomycin

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10
Q

HBV

A

Hep B
Recombinant Subunit
Insertion of HBV surface ag genes into yeast cells
Aluminum and formaldehyde

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11
Q

HPV

A 
Recom subunit 
2v - 16/18 oncogneic
4v - 16/18 oncogenic, and 6/11 warts 
9v 16/18/31/33/45/52/58 oncogenic and 6/11 warts 
Aluminum
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12
Q

IIV

A

Inactivated influenza
Inactivated virus in chicken eggs
Aluminum and thimersoal

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13
Q

LAIV

A

Live attenuated influenza

Cold-adapted live attenuated incubated in chicken eggs

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14
Q

RIV

A

Recombinant subunity influenza

INsertion of hemagluttinin genes into baculuvirus cultured in insect cells

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15
Q

MMR

A

Live attenuated
Derived strains of virus in chicken eggs
Hydrolyzed gelatin and neomycin

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16
Q

IPV

A

Polio
Inactivated
Inactivated type 1,2,3 cultured in calf
Formaldehyde, streptomycin and polymyxin

17
Q

RV1/RV5

A

Rotovirus
Live attenuated
RV1 - capsid protein
RV5 - G1-4 capside proteins and P7 attachment proteins

18
Q

HVV

A

Herpes zoster
Live attenuated
Varicella zoster at 19,400 PFUs
Hydrolyzed gelatin and neomycin

19
Q

VAR

A

Varicella
Live attenuated
V zoster at 1350 PFUs
Hydrolyzed geltin and neomycin

20
Q

Live vaccine induction

A

Disseminate to reach target tissues and activate PRRs

21
Q

Nonlive vaccine induction

A

Contain PAMOs and only trigger PRRs at site of injection

IM delivery key because lotsof dendritic cells

22
Q

Live attenuated characteristics

A

Recombined DNA to less virulent form
Strong cellular and AB response with few doses
Possiblity exist to revert to virulent form

23
Q

IMmune activation does NOT occur with

A

Circulating AB

24
Q

Inactivated characteristics

A

Kill
Safer
Stimulate weaker response (mostly HMI with a little CMI)…need boosters

25
Q

Subunit characteristics

A

Only antigens that best stimulate immune system
Protein or polysach (polysach only for over 2 y/o)
Can culture then use chemicals
OR recombinant where insert microbe genomes into another organism to produce proteins

26
Q

Toxoid vaccines

A

Inactivate toxins with formaldehyde

Immune system produces ABs to block toxin

27
Q

POlysach conjugate vaccine

A 
Link antigens (carb) to protein for immune system recognition 
Immune response moved to germinal centers, T-dependent response, more long term memory

Can use in children less than 2

28
Q

Type of vaccine order

A

Live>inact>protein>polysach

29
Q

Age of immunization

A

AB responses poor under 1 year

Poor AB response to polysacch less than 2 year

30
Q

Intervals between immunization

A

Primary doses 3 weeks apart (allows waves of ag-sepcific responses)
Boosting 4+ months after pirmary (allows maturation of B memory cells)

31
Q

Antibioti/formaldehyde/thimerosal/gelatin purpose

A

AB - prevent growth of bacteria
Form - inactivate viruses/toxins
Thimerosal - Prevent growth of bacteria
Gelatin - helps stabilize lives viruses

32
Q

Adjuvants

A 
TLR ligand 
Enhance uptake by APCs 
Inflammasome activation (IL-1)
Enahnce immune presnetation 
Immune cell recruitment
33
Q

Aluminum used to

A

Enahcnes ag uptake and activate inflammasomes

34
Q

Lipid A analogues used

A

MPL in 2vHPV

TLR ligand and immune cell recruitment

Foundations 7 (19 decks)

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