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Foundations 7 > Herpesviruses > Flashcards

Herpesviruses Flashcards

1
Q

Structure/genomis

A

dsDNA enveloped

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2
Q

Herpes viruses we need to know and number

A 
HSV 1 
HSV 2 
3 = VZV
5 = CMV
8 = HHV (Karposi)
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3
Q

Alpha herpes viruses

A

Latent infection in neurons

HSV and VZV (1-3)

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4
Q

Gamma herpes viruses

A

Lymphotrophic and infected cells proliferate (HHV-8)

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5
Q

Beta herpes viruses

A

Infected cells tend to enlarge and lymphotrophic (CMV)

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6
Q

HHV 1 common name, transmission, primary infection site, dz, and latent infection site

A 
Herpes simplex virus 1 
Close contact 
Mucoepithelial cells
Fever blisters, ocular lesions, encephalitis 
Nerve ganglia
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7
Q

HHV 2 common name, transmission, primary infection site, dz, and latent infection site

A

Herpes simplex virus 2
Close contact
Sexual transmission/mucoepithelail cells
Genital/anal lesions, severe neonatal infections, meningitis
Nerve ganglia

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8
Q

HHV 3 common name, transmission, primary infection site, dz, and latent infection site

A 
VZV
Respiratory inhalation/close contact 
Mucoepithelial cells 
Chickenpox (primary), shingles (reactivation)
Nerve ganglia
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9
Q

HHV 5 common name, transmission, primary infection site, dz, and latent infection site

A

CMV
Close contact, sexual transmission, congenital, blood to blood transplant
Mono, severe congential infection, infections in immunocompromised
Monocytes, neutrophils, vascular nedothelial cells

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10
Q

HHv 8common name, transmission, primary infection site, dz, and latent infection site

A 
Karposi sarcoma associated/KSHV
Sexual transmission
B lymphocytes and peripheral blood PMNs 
Tumors including kaposi sarcoma, some B cells 
Virus infected tumors
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11
Q

What makes 1,2,and 3 unqieu

A

Latency

Reactivation (especially in immunocompromised)

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12
Q

HHV lesion appearance

A

Look like vesicles on a red background

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13
Q

Varicella manifestation

A

Generalized rash with lots of lesions

May have fever early

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14
Q

HSV 1 and 2 latency

A

Will occur at same nerve that orignial infection occurred

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15
Q

Primary dz of HSV 1 and 2 vs. VZV

A

HSV 1 and 2 typically localized while VZV is systemic

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16
Q

Reactivated VZV pattern

A

Dermatome pattern that typically does not cross the midline

17
Q

CMV symptoms of primary infection

A

Mononucleosis

Fever, fatigue, sore throat, swollen lymph glands

18
Q

CMV in immunocompromised major symptoms

A

Chorioretinitis (Think HIV)

19
Q

HHV 8

A

Kaposi’s sarcoma - cutaneous lesions with or without internal involvement…** look for low CD4 count, only time this will occur

Foundations 7 (19 decks)

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