Herpesviruses Flashcards
Structure/genomis
dsDNA enveloped
Herpes viruses we need to know and number
HSV 1 HSV 2 3 = VZV 5 = CMV 8 = HHV (Karposi)
Alpha herpes viruses
Latent infection in neurons
HSV and VZV (1-3)
Gamma herpes viruses
Lymphotrophic and infected cells proliferate (HHV-8)
Beta herpes viruses
Infected cells tend to enlarge and lymphotrophic (CMV)
HHV 1 common name, transmission, primary infection site, dz, and latent infection site
Herpes simplex virus 1 Close contact Mucoepithelial cells Fever blisters, ocular lesions, encephalitis Nerve ganglia
HHV 2 common name, transmission, primary infection site, dz, and latent infection site
Herpes simplex virus 2
Close contact
Sexual transmission/mucoepithelail cells
Genital/anal lesions, severe neonatal infections, meningitis
Nerve ganglia
HHV 3 common name, transmission, primary infection site, dz, and latent infection site
VZV Respiratory inhalation/close contact Mucoepithelial cells Chickenpox (primary), shingles (reactivation) Nerve ganglia
HHV 5 common name, transmission, primary infection site, dz, and latent infection site
CMV
Close contact, sexual transmission, congenital, blood to blood transplant
Mono, severe congential infection, infections in immunocompromised
Monocytes, neutrophils, vascular nedothelial cells
HHv 8common name, transmission, primary infection site, dz, and latent infection site
Karposi sarcoma associated/KSHV Sexual transmission B lymphocytes and peripheral blood PMNs Tumors including kaposi sarcoma, some B cells Virus infected tumors
What makes 1,2,and 3 unqieu
Latency
Reactivation (especially in immunocompromised)
HHV lesion appearance
Look like vesicles on a red background
Varicella manifestation
Generalized rash with lots of lesions
May have fever early
HSV 1 and 2 latency
Will occur at same nerve that orignial infection occurred
Primary dz of HSV 1 and 2 vs. VZV
HSV 1 and 2 typically localized while VZV is systemic