Viral Hepatitis

Question 1

CM of Hep B infection

Complication

Presentation of these comps

Answer 1

fatigue, anorexia, naseua, RUQ fullness, fever

Immune complexes formed by HBsAg and anti-HBsAg can lead to hypersensitivity rxns

Arthritis, rash, vasculitis, arthralgia

Question 2

Acute infection

Core period

Recovery, HBs/HBe

Presence of HBe indicates

Answer 2

virus dividing, produces HBsAg and anti-HBsAg

only anti-HBc present

disappear, anti-HBsAg and anti-HBeAg appear

transmissability

Question 3

Hep C- CM present in

Chronic infection can result in

Viral replication is without proofreading, so

Answer 3

10-20 yrs after infection

Liver cirrhosis and HCC

Mutation rate is high

Question 4

Hep A prodrome sx

1-2 wks after peak viral shedding sx

Hep E

Areas

Hep E fulminant hepatic failure in

Answer 4

fever, malaise, nausea, vomiting

dark urine/stool, RUQ pain

more likely to get jaundice, ab pain, hepatomegaly

Asia, Africa, ME, Central America

Pregnant women

Question 5

Replication of ssRNA + genome

Answer 5

RNA enters cell, trsnl

produce - strand and proteins (RDRP)

• strand serves as complment

RDRP cnverts to +

assemply into capsid