Gastro embryo Flashcards
Week 4
week 5
Endodermal gut tube forms foregut, midgut, hindgut (neural crest migrates)
Rapid endodermal prolif of gut tube occludes lumen (form solid tube)
Primordial lung buds form (foregut)
Lateral septation to separate respiratory/GI tracts
Hindgut ends in cloaca cont w allantois (urorectal septum forms from mesoderm)
Week 6
Week 7
Midgut intest loop herniates into yolk sac
Mesoderm folds in 4 direction (cephalic/caudal/R/L) converging on umbilical ring
NCC descend to hindgut, form ganglion cells
Vitelline duct obliterated (separates midgut/yolk sac)
Week 8
pleuroperitoneal membrane extends and fuses with septum transversum to form diaphragm
Cloacal membrane divides/merges with urorectal septum seperating urogenital/anorectal tracts
Week 9
week 10
Expand mesoderm mesentery around gut tube/apoptosis of endoderm recanalizes gut tube
midgut intestinal loop rotates 180 CCW and retracts
Polyhydramnios results from
Genetic abnormalities
CNS anomalies (impaired swallowing)
Gestational diab
Downs, Tri 18
Anencephaly, hydrancephaly, holoproscencephaly
Diaphragm hernia
Duodenal atresia
Cause
presentation
DH- failure of PP fold to fuse with ST
1st few hours, RD, scaphoid ab
DA- failure of complete recanalization of foregut
after 1st few feeds, bilious emesis, 50% have downs
TEF
incomplete lateral septation of foregut
1st few hours, recurrent bilious emesis, small bowel obstruction (emesis)
Diaphragmatic hernia complications
SI in left chest, pushing mediastinum to R\
Liver in chest
Problems with cloacal membrane division
Mesodermal lateral folding
Disorder and presentation
Anal atresia- malformed/absent anus, failed meconium, VACTERL
Omphalocele- umbilical sac contains intestine and liver/spleen
Prob with NCC migration
Obilteration of omphalomesenteric duct
disorder and presentation
Hirschprung (cong aganglionic megacolon)- failure to pass meconium/lifelong constip
Meckel diver- painless rectal bleeding, intusscepstion, diverticulitis
Meconium
Composed of
Passed within
Failed
products of secretion in utero
Glycerophospholipids from lung
Vernix (sebum, desquamated cells, languo, scalp hair)
48 hrs usually
Hirschprung, anal atresia, meconium ileus (obstruction from thick meconium), small left colon syndrome (diabetic mother)
Omphalocele
Gastroschisis
Failue of mesoderm folding, yolk sac outside body
Ischemia, intestines outside body
R shoulder pain
Stomach/duodenum
Small intestine
Colon
Potential complications front C4, T5-L1
Diaphragmatic irritation, perforated ulcer, liver inflamm, cholecystitis
PU
Appendicitis, SBO
Colon obstruction
L shoulder pain
Stomach
Liver/gall bladder
Pancreas
Rectum
Complications on back T5-L1
Diaphragmatic irritation, perforated ulcer, splenic rupture
GOO, ulcer
biliary colic, cholecystitis
pancreatitis
UC, obstruction
Seat belt sign/bruising
Blunt abdominal trauma common injuries
Penetrating trauma injuries
think small bowel
Spleen, liver, diaphram (rib fractures), bowel (seat belt)
Bowel, liver, diaphragm
