Eosinophilic Esophagitis

Question 1

EoE process

Antigens trigger

Pts typically have

Answer 1

chronic, immune mediated due to antigen sensitization

Type 2 helper T cell response (Th2), releasing IL5 (eosinophils) and IL13 (eotaxin, more eosinophil recruitment)

Other atopic cx (allergies, rhinits, asthma etc)
may be a genetic link

Question 2

Young child CM

Teenagers

Adults

Answer 2

chest/ab pain, N/V, food aversion, failure to thrive

Dysphagia to solid foods/food impaction

Heartburn, CP, food impaction/dysphagia

Question 3

EoE number 1 complication

Answer 3

Esophageal stricture