Achalasia

Question 1

Achalasia patho

Answer 1

lost ganglion cells- loses NO prodxn & inhibitory neurons with sparing of cholinergic neurons

Question 2

Dx suspected in individuals with

Diagnostic test

Barium study findings

Answer 2

Dysphagia to l/s and retained food in esophagus

Esophageal manometry- lack of peristalsis/relaxation

Dilated esophagus, narrow GE jxn with beak appearance