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J Derm > Vesicubullous disease > Flashcards

Vesicubullous disease Flashcards

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Dermatology Board Prep flashcards
1
Q

what are the 4 main types of vesicubullous disease

A

pemphigus vulgaris
bullous pemphigoid
dermatitis herpetiformis (DH)
epidermolysis bullosa (EB)

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2
Q

is pemphigus vulgaris a autoimmune disease

A

yes

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3
Q

is pemphigus vulgaris superficial or deep in comparison to bullous pemphigoid?

which layer does it affect

A 
Superficial = pemphigus vulgariS
Deep = bullous pemphigoiD

pemphigus vulgaris affects the epidermis

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4
Q

is pemphigus vulgaris serious

A

yes it can be fatal

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5
Q

which vesicubullous disease is most common

A

pemphigus vulgaris

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6
Q

how does pemphigus vulgaris present (3+locations)

A

painful blisters
burst easily
leaves ulcerated lesions

location - mouth mucosa (plus scalp, axilla, groin, trunk)

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7
Q

what is nikolsky sign

A

when the top layer of skin slips away form lower layers of skin when rubbed slightly

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8
Q

is nikolsky sign positive or negative in pemphigus vulgaris

A

positive

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9
Q

when is nikolsky sign negative

A

in bullous pemphigoid

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10
Q

what is acantholysis

A

breakdown of intercellular adhesion sites = skin falls apart

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11
Q

does acantholysis happen in pemphigus vulgaris

A

yes

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12
Q

what is the treatment of pemphigus vulgaris

A

steroids
topical emollients
topical steroids

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13
Q

prognosis of pemphigus vulgaris

A

fatal if untreated

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14
Q

which age group does bullous pemphigoid present in

A

elderly

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15
Q

is bullous pemphigoid superficial or deep in comparison to pemphigus vulgaris?

which layer does it affect

A 
Deep = bullous pemphigoiD
Superficial = pemphigus vulgariS

at the De junction

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16
Q

presentation of bullous pemphigoid

A

itchy but cant burst (too deep)

blistering (occurs after itch)

17
Q

does acantholysis occur in bullous pemphigoid

A

no, just in pemphigus vulgaris

18
Q

what is the pathophysiology of bullous pemphigoid

A

IgG react with antigens in basal cells = damage occurs

19
Q

is nikolsky sign negative or positive in bullous pemphigoid

A

negative - the top layer of skin does NOT slip away when slightly rubbed

20
Q

treatment of bullous pemphigoid (similar to pemphigus but with something additional)

A

steroids
tetracycline ANTIBIOTICS (different from pemphigus)
topical emollients
topical steroids

21
Q

is dermatitis herppetifrormis common or rare

A

rare

22
Q

which GI condition is dermatitis herpetiformis strongly associated with

A

coeliac disease

23
Q

which antibody is involved in dermatitis herpetiformis

A

IgA

24
Q

where does the pathophysiology of dermatitis herpetiformis take place

A

DE junction

25
Q

what is the presentation of dermatitis herpetiformis (2 + location)

A

v itchy lesions on extensor surfaces
GI symptoms - fatigue, bloating, change in bowel habit

location - extensor surfaces eg elbows, knees, buttocks symmetrically

26
Q

aetiology of epidermolysis bullosa (EB) in children

A

genetic

27
Q

aetiology of epidermolysis bullosa (EB) in adults

what is this also known as

A

autoimmune

EB aquisita

28
Q

how does epidermolysis bullosa present

A

skin blistering in response to minor injury

29
Q

what are the 3 types of epidermolysis bullosa

A

simplex
junctional
dystrophic

30
Q

where does simplex epidermolysis bullosa affect

how does it present (scarring)

A

epidermis

no scarring involved

31
Q

where does junctional epidermolysis bullosa affect

how does it present (scarring)

A

epidermal-dermal junction

some scarring

32
Q

where does dystrophic epidermolysis bullosa affect

how does it present (scarring)

A

dermis

heals with v bad scarring, can cause loss/fusion of digits

33
Q

prognosis

A

very variable! cant tell at birth

34
Q

what does dermatitis herpetiformis look like on histology

A

papillary dermal microabscesses

35
Q

IgA positive dermal papillae

A

dermatitis herpetiformis

J Derm (23 decks)

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