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J Derm > Psoriasis > Flashcards

Psoriasis Flashcards

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Dermatology Board Prep flashcards
1
Q

what % of the population have psoriasis

A

2-3

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2
Q

aetiology of psoriasis

A

environmental factor in genetically susceptible individuals

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3
Q

what are the environmental triggers of psoriasis (4)

A

stress
infection eg HIV, resp tract infection
drugs eg beta blockers, lithium
tonic water (quinolone)

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4
Q

what 2 things aggravates psoriasis

A

smoking

drinking

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5
Q

what MSK condition is closely associated with psoriasis

A

rheumatoid arthritis

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6
Q

are T or B cells involved in the inflammatory process of psoriasis

A

T cells

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7
Q

increased T cells in psoriasis causes what other immune complex to increase

A

interleukins

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8
Q

high levels of interleukins causes AMP release to increase or decrease

A

increase

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9
Q

high levels of AMP in the skin cause which layer of the skin to thicken

A

keratin layer

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10
Q

is the overall immune response quick or delayed

A

delayed

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11
Q

parakeratosis is seen on histology in psoriasis patients, what does this mean

A

presence of nuclei in keratin layer

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12
Q

how does the keratin layer look in comparison to normal skin in psoriasis

A

thickened

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13
Q

what is guttate psoriasis
acute or chronic?
widespread or localised?
aetiology

A

acute
widespread
after recent antibiotic treatment

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14
Q

where does palmoplantar pustular psoriasis occur

A

soles of feet/palms of hands

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15
Q

is erythrodermic pustular psoriasis;
acute/chronic?
severe or not?
widespread/localised?

A

acute
v severe
covered top to toe

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16
Q

what is the presentation of psoriasis (4+location)

A

thin silver/salmon pink scaly plaques
itchy
erythroderma
elongation of rete ridges

location - extensor surfaces eg elbows, knees, buttocks, symmetrically

17
Q

what is the koebner phenomenon

A

psoriasis in an area of previous skin trauma

18
Q

what nail changes are associated with psoriasis (4)

A

pitting
onycholysis
white nails
subungal hyperkeratosis

19
Q

what is onycholysis

A

when the nail lifts up from the nail bed

20
Q

how does the PASI scoring system work

A

depending on % of skin covered

21
Q

what is the cure for psoriasis

A

no cure, self limiting

22
Q

what is the treatment for chronic psoriasis (7)

A 
emollients - FIRST LINE
vit D analogues 
coal tar (messy)
dithranol 
steroid ointments (for face/groin/flexures)
keratolytic  
immunosuppression (methotrexate)
23
Q

what is a rare complication of psoriasis

A

plaques can turn into malignant squamous cell carcinoma

24
Q

what does psoriasis increase risk of

A

cardiovascular disease

25
Q

drugs that can aggravate/trigger psoriasis

A 
beta blockers (eg propranolol) 
lithium

J Derm (23 decks)

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