+ve Selecrion Flashcards
1
Q
Where does it take place?
A
Lymph nodes
2
Q
Where do B cells with BCR’s enter ?
A
LN and if BCR can bind to antigens it is activated
3
Q
Does it need 2 signals ?
A
Yes for full activation
4
Q
Where does B cell migrate too once activated ?
A
Follicle in the dark zone
5
Q
What happens in dark zone?
A
B cells undergo somatic hypermutation
6
Q
Where do B cells enter after the dark zone ?
A
The light zone ?
7
Q
What happens in the light zone?
A
B cells with BCRs that have high affinity for the antigen receive the survival signal
8
Q
What happen ?
A
B cell can become plasma or memory cell
