Combinatoral Diversity For iG Decelopment

Question 1

Is the following statement true ?
Each b cell is designed to respond to one antigen?

Answer 1

True

Question 2

How does a b cell respond to one antigen?

Answer 2

It needs a specific antibody protein

Question 3

Is the following statement true ?
Because there is such diversity with antigens one gene to protein isn’t suffice ?

Answer 3

It is true because a bigger genome is required

Question 4

What causes an increase in genome ?

Answer 4

Somatic recombination of variable gene regions in heavy and light chains

Question 5

What enzymes support this process ?

Answer 5

Rag1/2

Question 6

What do rag1/2 do in the heavy chain

Answer 6

Enable random segments of V,D&J

Question 7

What do rag1/2 do in the light chain?

Answer 7

Enable random segments of V&J

Question 8

Why is somatic recombination important ?

Answer 8

Allows development of unique receptors for specific responses

Question 9

Why is generating vast repertoire important ?

Answer 9

Protect against a variety of pathogens that can be encountered which is critical for immune surveillance